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TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.

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Title: TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
Authors: Chen X; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Zhou Q; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China., He Y; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Wang Y; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Jiang Y; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Ren Y; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Ren Y; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Cai J; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Yu H; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Chen C; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China., Cheng K; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China., Xie P; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China. xiepeng@cqmu.edu.cn.
Source: Translational psychiatry [Transl Psychiatry] 2025 Oct 06; Vol. 15 (1), pp. 366. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Cai+J%22">Cai J</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Cheng+K%22">Cheng K</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Xie+P%22">Xie P</searchLink>; National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. xiepeng@cqmu.edu.cn.; Guangyang Bay Laboratory, Chongqing Institute for Brain and Intelligence, Chongqing, China. xiepeng@cqmu.edu.cn.
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