Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV.
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| Title: | Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV. |
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| Authors: | Mkhize NN; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Zhang B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Brackett C; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Elyanu PJ; Baylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda., Tapley A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Dadabhai S; Johns Hopkins Research Project, Blantyre, Malawi., Hu J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Do BTN; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Schuster DJ; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Heptinstall J; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Sawant S; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Seaton K; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Sarzotti-Kelsoe M; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Hudson A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Jin Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bhebhe S; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Kaldine H; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Modise T; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Mgodi NM; Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe., Andriesen J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Randhawa AK; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Fisher LH; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kee JJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Magaret CA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Peng J; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kenny A; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.; Duke Global Health Institute, Duke University, Durham, NC, USA., Carpp LN; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Chen Z; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Pennsylvania, PA, USA., Heng S; Department of Biostatistics, School of Global Public Health, New York University, New York, NY, USA., Villaran M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Takalani A; Hutchinson Center Research Institute of South Africa, Chris Hani Baragwanath Academic Hospital, Soweto, South Africa., Le Roux B; Hutchinson Center Research Institute of South Africa, Chris Hani Baragwanath Academic Hospital, Soweto, South Africa., Wilkinson E; KwaZulu-Natal Research Innovation & Sequencing Platform, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for Epidemic Response & Innovation, Stellenbosch, South Africa., Odhiambo J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Hutchinson Center Research Institute of South Africa, Chris Hani Baragwanath Academic Hospital, Soweto, South Africa., Shah P; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Polakowski L; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Yacovone M; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Samandari T; COVID-19 Prevention Network, Seattle, WA, USA., Chirenje Z; Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe., Makhema J; Botswana Harvard AIDS Institute, Gaborone, Botswana., Kamuti E; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Njekwa K; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Nuwagaba-Biribonwoha H; ICAP at Columbia University, Eswatini Prevention Center, Mbabane, Eswatini.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Baguma A; Baylor College of Medicine Children's Foundation-Uganda, Kampala, Uganda., Badal-Faesen S; Clinical HIV Research Unit / Helen Joseph Clinical Research Site, Johannesburg, South Africa., Brumskine W; The Aurum Institute, Rustenburg Clinical Research Site, Rustenburg, South Africa., Coetzer S; Synexus Helderberg, Cape Town, South Africa., Dawson R; University of Cape Town Lung Institute Clinical Research Site, Cape Town, South Africa., Delany-Moretlwe S; Wits RHI University of the Witwatersrand, Johannesburg, South Africa., Diacon AH; TASK, Cape Town, South Africa., Fry S; FAMCRU Family Clinical Research Unit, Cape Town, South Africa., Gill K; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Madikida A; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Hoosain ZAE; Josha Research Clinical Research Site, Bloemfontein, South Africa., Hosseinipour MC; Malawi Clinical Research Site, Lilongwe, Malawi.; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, CA, USA., Inambao M; CFHRZ - Ndola Clinical Research Site, Ndola, Zambia., Innes C; The Aurum Institute, Klerksdorp Clinical Research Site, Klerksdorp, South Africa., Innes S; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Kalonji D; South African Medical Research Council, Isipingo Clinical Research Site, KwaZulu-Natal, South Africa., Mwape H; UNC Global Projects / Kamwala District Health Centre, Lusaka, Zambia., Kassim P; Soweto - Kliptown Clinical Research Site, Soweto, South Africa., Kamanga MC; Johns Hopkins Research Project-Kamuzu University of Health Sciences, Blantyre, Malawi., Kilembe W; CFHRZ Clinical Research Site, Lusaka, Zambia., Laher F; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Witwatersrand, South Africa., Malahleha M; Synergy Biomed Research Institute, East London, South Africa., Maluleke VL; MERC Middelburg, Middelburg, South Africa., Mboya G; Kisumu Clinical Research Site, Kisumu, Kenya., Madiega PA; Kenya Medical Research Institute, Nairobi, Kenya., McHarry K; TASK Eden, Western Cape, South Africa., Mitha E; Newtown Clinical Research, Johannesburg, South Africa., Duki Y; Aurum Tembisa Clinic 4, Gauteng, South Africa., Mda P; Nelson Mandela Academic Clinical Research Unit, Walter Sisulu University, Mthatha, South Africa., Moerane M; Nelson Mandela Academic Clinical Research Unit, Walter Sisulu University, Mthatha, South Africa., Moloantoa T; PHRU Matlosana Clinical Research Site, Klerksdorp, South Africa., Nuwamanya S; Joint Clinical Research Centre, Lubowa, Uganda., Mahomed S; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa., Naicker V; South African Medical Research Council, Tongaat Clinical Research Site, KwaZulu-Natal, South Africa., Nana A; Soweto - Kliptown Clinical Research Site, Soweto, South Africa., Nanvubya A; UVRI-IAVI HIV Vaccine Program Ltd. Clinical Research Site, Entebbe, Uganda., Kawoozo B; UVRI-IAVI HIV Vaccine Program Ltd. Clinical Research Site, Entebbe, Uganda., Nchabeleng M; MeCRU Clinical Research Site, Pretoria, South Africa., Otieno W; Kombewa Clinical Research Site, Kisumu, Kenya.; Maseno University School of Medicine, Kisumu, Kenya., Potgieter EL; Synexus Stanza Clinical Research Centre Clinical Research Site, Pretoria, South Africa., Potloane D; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa., Punt Z; PHOENIX Pharma (Pty) Ltd, Port Elizabeth, South Africa., Said J; Moi University Clinical Research Centre, Eldoret, Kenya., Singh Y; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Kassim S; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., van der Vendt D; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Tayob MS; MERC Kempton, Kempton, South Africa., Vahed Y; MERC Welkom, Welkom, South Africa., Wabwire DO; MU-JHU Research Collaboration Clinical Research Site, Kampala, Uganda., Kublin JG; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Gray GE; South African Medical Research Council, Pretoria, South Africa., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Kotze P; Qhakaza Mbokodo Research Clinic, Ladysmith, South Africa., Garrett N; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa., Hural J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Ferrari G; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Andersen-Nissen E; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Cape Town HVTN Immunology Laboratory, Hutchinson Centre Research Institute of South Africa, Cape Town, South Africa., Montefiori D; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA., Moore PL; National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.; Faculty of Health Sciences, SAMRC Antibody Immunity Research Unit, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Tomaras GD; Departments of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA. gdt@duke.edu., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org.; Department of Biostatistics, University of Washington, Seattle, WA, USA. pgilbert@fredhutch.org.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. pgilbert@fredhutch.org. |
| Corporate Authors: | CoVPN 3008 Study Team |
| Source: | Nature communications [Nat Commun] 2025 Oct 06; Vol. 16 (1), pp. 8876. Date of Electronic Publication: 2025 Oct 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63948-4 |
