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Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.

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Title: Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.
Authors: Sposito M; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Belluomini L; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Nocini R; Otolaryngology-Head and Neck Surgery Department, Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Insolda J; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Scaglione IM; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Menis J; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Simbolo M; Section of Pathology, Department of Diagnostics and Public Health, University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Lugini A; Medical Oncology Unit, AO San Giovanni Addolorata Hospital, Via dell'Amba Aradam, 9, 00184, Rome, Italy., Buzzacchino F; Medical Oncology Unit, San Giuseppe Moscati Hospital, Strada Statale 7 Appia, 74121, Taranto, Italy., Verderame F; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy., Spinnato F; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy., Aprile G; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy., Calvetti L; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy., Occhipinti M; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori, Via Giacomo Venezian, 1, 20133, Milan, Italy., Marinelli D; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Division of Medical Oncology B, Policlinico Umberto I, Viale del Policlinico, 155, 00161, Rome, Italy., Veccia A; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 9, 38122, Trento, Italy., Lombardo F; Lung Unit, Ospedale Pederzoli, Via Monte Baldo, 24, 37019, Peschiera del Garda, Verona, Italy., Soto Parra HJ; Medical Oncology, Azienda Ospedaliero Universitaria Policlinico 'G. Rodolico-S. Marco', Via S. Sofia, 78, 95123, Catania, Italy., Ferraù F; UOC Oncologia, Taormina, Contrada Sirina, 98039, Taormina, Italy., Savastano C; Medical Oncology Unit, San Giovanni di Dio e Ruggi d'Aragona, Via San Leonardo, 1, 84131, Salerno, Italy., Porta C; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy., Pradelli L; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy., Sicari E; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy., Castellani S; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy., Malapelle U; Department of Public Health, University Federico II of Naples, Via Pansini, 5, 80131, Naples, Italy., Passiglia F; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole,10, 10043, Orbassano, Turin, Italy., Bria E; Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Pilotto S; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy. sara.pilotto@univr.it., Milella M; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.
Source: Scientific reports [Sci Rep] 2025 Oct 06; Vol. 15 (1), pp. 34807. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-025-18662-y