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Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.

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Title: Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.
Authors: Sposito M; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Belluomini L; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Nocini R; Otolaryngology-Head and Neck Surgery Department, Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Insolda J; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Scaglione IM; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Menis J; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Simbolo M; Section of Pathology, Department of Diagnostics and Public Health, University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy., Lugini A; Medical Oncology Unit, AO San Giovanni Addolorata Hospital, Via dell'Amba Aradam, 9, 00184, Rome, Italy., Buzzacchino F; Medical Oncology Unit, San Giuseppe Moscati Hospital, Strada Statale 7 Appia, 74121, Taranto, Italy., Verderame F; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy., Spinnato F; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy., Aprile G; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy., Calvetti L; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy., Occhipinti M; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori, Via Giacomo Venezian, 1, 20133, Milan, Italy., Marinelli D; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Division of Medical Oncology B, Policlinico Umberto I, Viale del Policlinico, 155, 00161, Rome, Italy., Veccia A; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 9, 38122, Trento, Italy., Lombardo F; Lung Unit, Ospedale Pederzoli, Via Monte Baldo, 24, 37019, Peschiera del Garda, Verona, Italy., Soto Parra HJ; Medical Oncology, Azienda Ospedaliero Universitaria Policlinico 'G. Rodolico-S. Marco', Via S. Sofia, 78, 95123, Catania, Italy., Ferraù F; UOC Oncologia, Taormina, Contrada Sirina, 98039, Taormina, Italy., Savastano C; Medical Oncology Unit, San Giovanni di Dio e Ruggi d'Aragona, Via San Leonardo, 1, 84131, Salerno, Italy., Porta C; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy., Pradelli L; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy., Sicari E; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy., Castellani S; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy., Malapelle U; Department of Public Health, University Federico II of Naples, Via Pansini, 5, 80131, Naples, Italy., Passiglia F; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole,10, 10043, Orbassano, Turin, Italy., Bria E; Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy., Pilotto S; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy. sara.pilotto@univr.it., Milella M; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.
Source: Scientific reports [Sci Rep] 2025 Oct 06; Vol. 15 (1), pp. 34807. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Sposito+M%22">Sposito M</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Belluomini+L%22">Belluomini L</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Nocini+R%22">Nocini R</searchLink>; Otolaryngology-Head and Neck Surgery Department, Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Insolda+J%22">Insolda J</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Scaglione+IM%22">Scaglione IM</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Menis+J%22">Menis J</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Simbolo+M%22">Simbolo M</searchLink>; Section of Pathology, Department of Diagnostics and Public Health, University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Lugini+A%22">Lugini A</searchLink>; Medical Oncology Unit, AO San Giovanni Addolorata Hospital, Via dell'Amba Aradam, 9, 00184, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Buzzacchino+F%22">Buzzacchino F</searchLink>; Medical Oncology Unit, San Giuseppe Moscati Hospital, Strada Statale 7 Appia, 74121, Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Verderame+F%22">Verderame F</searchLink>; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Spinnato+F%22">Spinnato F</searchLink>; AO Ospedali Riuniti 'Villa Sofia- V. Cervello', Piazza Salerno, 1, 90146, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Aprile+G%22">Aprile G</searchLink>; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Calvetti+L%22">Calvetti L</searchLink>; Department of Clinical Oncology, San Bortolo General Hospital, Azienda ULSS8 Berica, Viale Ferdinando Rodolfi, 37, 36100, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Occhipinti+M%22">Occhipinti M</searchLink>; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori, Via Giacomo Venezian, 1, 20133, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marinelli+D%22">Marinelli D</searchLink>; Department of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.; Division of Medical Oncology B, Policlinico Umberto I, Viale del Policlinico, 155, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Veccia+A%22">Veccia A</searchLink>; Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 9, 38122, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Lombardo+F%22">Lombardo F</searchLink>; Lung Unit, Ospedale Pederzoli, Via Monte Baldo, 24, 37019, Peschiera del Garda, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Soto+Parra+HJ%22">Soto Parra HJ</searchLink>; Medical Oncology, Azienda Ospedaliero Universitaria Policlinico 'G. Rodolico-S. Marco', Via S. Sofia, 78, 95123, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Ferraù+F%22">Ferraù F</searchLink>; UOC Oncologia, Taormina, Contrada Sirina, 98039, Taormina, Italy.<br /><searchLink fieldCode="AU" term="%22Savastano+C%22">Savastano C</searchLink>; Medical Oncology Unit, San Giovanni di Dio e Ruggi d'Aragona, Via San Leonardo, 1, 84131, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Porta+C%22">Porta C</searchLink>; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Pradelli+L%22">Pradelli L</searchLink>; AdRes Health Economics and Outcome Research, Via Po, 14, 10124, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Sicari+E%22">Sicari E</searchLink>; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Castellani+S%22">Castellani S</searchLink>; Roche S.p.A., Piazza Cadorna, 6, 20900, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Malapelle+U%22">Malapelle U</searchLink>; Department of Public Health, University Federico II of Naples, Via Pansini, 5, 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Passiglia+F%22">Passiglia F</searchLink>; Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole,10, 10043, Orbassano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Bria+E%22">Bria E</searchLink>; Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168, Rome, Italy.; Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pilotto+S%22">Pilotto S</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy. sara.pilotto@univr.it.<br /><searchLink fieldCode="AU" term="%22Milella+M%22">Milella M</searchLink>; Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and Verona University and Hospital Trust (AOUI Verona), P.le L.A. Scuro, 10, 37134, Verona, Italy.
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