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Antiplatelet therapy through inhibition of P2Y12 and phosphodiesterase receptors by novel synthesis 1,3-dicyclohexylpyrimidine-2,4(1H,3H)-dione derivatives with computational evaluation.

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Title: Antiplatelet therapy through inhibition of P2Y12 and phosphodiesterase receptors by novel synthesis 1,3-dicyclohexylpyrimidine-2,4(1H,3H)-dione derivatives with computational evaluation.
Authors: Elsayed DA; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt. Electronic address: doaaatef641995@gmail.com., Soltan MK; Oman college of health sciences, Muscat, Oman; Department of Medicinal Chemistry, Faculty of Pharmacy Zagazig University, Egypt., Abd-El-Maksoud MA; Department of Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, Cairo, Egypt., Tantawy ES; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza 12622, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo 11517, Egypt., Shehab WS; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt., Saeed A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.; Sulaiman Bin Abdullah Aba Al-Khail-Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University, Islamabad 44000, Pakistan., Farag B; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt. Electronic address: basantfarag@zu.edu.eg.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Oct; Vol. 165, pp. 109009. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Elsayed+DA%22">Elsayed DA</searchLink>; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt. Electronic address: doaaatef641995@gmail.com.<br /><searchLink fieldCode="AU" term="%22Soltan+MK%22">Soltan MK</searchLink>; Oman college of health sciences, Muscat, Oman; Department of Medicinal Chemistry, Faculty of Pharmacy Zagazig University, Egypt.<br /><searchLink fieldCode="AU" term="%22Abd-El-Maksoud+MA%22">Abd-El-Maksoud MA</searchLink>; Department of Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Tantawy+ES%22">Tantawy ES</searchLink>; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AF%22">El-Sayed AF</searchLink>; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza 12622, Egypt.; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo 11517, Egypt.<br /><searchLink fieldCode="AU" term="%22Shehab+WS%22">Shehab WS</searchLink>; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.<br /><searchLink fieldCode="AU" term="%22Saeed+A%22">Saeed A</searchLink>; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.; Sulaiman Bin Abdullah Aba Al-Khail-Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University, Islamabad 44000, Pakistan.<br /><searchLink fieldCode="AU" term="%22Farag+B%22">Farag B</searchLink>; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, Egypt. Electronic address: basantfarag@zu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Oct; Vol. 165, pp. 109009. <i>Date of Electronic Publication: </i>2025 Sep 26.
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        Value: 10.1016/j.bioorg.2025.109009
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      – TitleFull: Antiplatelet therapy through inhibition of P2Y12 and phosphodiesterase receptors by novel synthesis 1,3-dicyclohexylpyrimidine-2,4(1H,3H)-dione derivatives with computational evaluation.
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              Text: 2025 Oct
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