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Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies.

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Title: Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies.
Authors: Fuchs SP; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Mondragon PG; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Zabizhin R; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Tomer S; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA., Wang L; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA., Cook E; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA., Dudley DM; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Weisgrau KL; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Furlott J; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Coonen J; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Alexander E; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Xie J; Department of Genetics & Cellular Medicine, Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA., Gao G; Department of Genetics & Cellular Medicine, Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA., Termini JM; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Martinez-Navio JM; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Zhen A; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA. AZhen@mednet.ucla.edu., Desrosiers RC; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA. r.desrosiers@med.miami.edu.
Source: Nature communications [Nat Commun] 2025 Oct 07; Vol. 16 (1), pp. 8906. Date of Electronic Publication: 2025 Oct 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Fuchs+SP%22">Fuchs SP</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mondragon+PG%22">Mondragon PG</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zabizhin+R%22">Zabizhin R</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Tomer+S%22">Tomer S</searchLink>; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cook+E%22">Cook E</searchLink>; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dudley+DM%22">Dudley DM</searchLink>; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Weisgrau+KL%22">Weisgrau KL</searchLink>; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Furlott+J%22">Furlott J</searchLink>; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Coonen+J%22">Coonen J</searchLink>; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+E%22">Alexander E</searchLink>; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Genetics & Cellular Medicine, Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+G%22">Gao G</searchLink>; Department of Genetics & Cellular Medicine, Horae Gene Therapy Center, UMass Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Termini+JM%22">Termini JM</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Martinez-Navio+JM%22">Martinez-Navio JM</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zhen+A%22">Zhen A</searchLink>; Department of Hematology/Oncology, University of California-Los Angeles, Los Angeles, CA, USA. AZhen@mednet.ucla.edu.<br /><searchLink fieldCode="AU" term="%22Desrosiers+RC%22">Desrosiers RC</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA. r.desrosiers@med.miami.edu.
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