Optogenetic induction of subcellular Ca2+ events in megakaryocytes and platelets using a highly Ca2+-conductive channelrhodopsin.

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Title: Optogenetic induction of subcellular Ca2+ events in megakaryocytes and platelets using a highly Ca2+-conductive channelrhodopsin.
Authors: Zhang Y; Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany., Yu-Strzelczyk J; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany., Sisario D; Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany., Holzapfel R; Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany., Nagy Z; Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany., Xu C; Department of Cardiology, Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Shen C; Department of Cardiology, Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Nagel G; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany., Gao S; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany. gao.shiqiang@uni-wuerzburg.de., Bender M; Institute of Experimental Biomedicine-Chair I, University Hospital Würzburg, Würzburg, Germany. bender_m1@ukw.de.
Source: Communications biology [Commun Biol] 2025 Oct 07; Vol. 8 (1), pp. 1433. Date of Electronic Publication: 2025 Oct 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-08924-w