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Sperm sequencing reveals extensive positive selection in the male germline.

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Title: Sperm sequencing reveals extensive positive selection in the male germline.
Authors: Neville MDC; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Lawson ARJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Sanghvi R; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Abascal F; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Pham MH; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Cagan A; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Nicola PA; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Bayzetinova T; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Baez-Ortega A; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Roberts K; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Lensing SV; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Widaa S; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Alcantara RE; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics, Saffron Walden, UK., García MP; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Wadge S; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Small K; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., Martincorena I; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Hurles ME; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Rahbari R; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8089), pp. 421-428. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Sperm sequencing reveals extensive positive selection in the male germline.
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  Data: <searchLink fieldCode="AU" term="%22Neville+MDC%22">Neville MDC</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Lawson+ARJ%22">Lawson ARJ</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Sanghvi+R%22">Sanghvi R</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Abascal+F%22">Abascal F</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Pham+MH%22">Pham MH</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Cagan+A%22">Cagan A</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Nicola+PA%22">Nicola PA</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bayzetinova+T%22">Bayzetinova T</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Baez-Ortega+A%22">Baez-Ortega A</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+K%22">Roberts K</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Lensing+SV%22">Lensing SV</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Widaa+S%22">Widaa S</searchLink>; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Alcantara+RE%22">Alcantara RE</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22García+MP%22">García MP</searchLink>; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wadge+S%22">Wadge S</searchLink>; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Small+K%22">Small K</searchLink>; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Martincorena+I%22">Martincorena I</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Hurles+ME%22">Hurles ME</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Rahbari+R%22">Rahbari R</searchLink>; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Nov; Vol. 647 (8089), pp. 421-428. <i>Date of Electronic Publication: </i>2025 Oct 08.
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