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Somatic mutation and selection at population scale.

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Title: Somatic mutation and selection at population scale.
Authors: Lawson ARJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Abascal F; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Nicola PA; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Lensing SV; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Roberts AL; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kalantzis G; Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK., Baez-Ortega A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Brzozowska N; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., El-Sayed Moustafa JS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Vaitkute D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Jakupovic B; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Nessa A; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Wadge S; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Österdahl MF; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Paterson AL; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Rassl DM; Department of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Alcantara RE; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics Limited, Saffron Walden, UK., O'Neill L; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Widaa S; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Austin-Guest S; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Neville MDC; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Przybilla MJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Cheng W; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Morra M; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Sykes L; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Mayho M; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Müller-Sienerth N; Sequencing Operations, Wellcome Sanger Institute, Hinxton, UK., Williams N; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Alexander D; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Harvey LMR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Clarke T; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Byrne A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Blundell JR; Early Cancer Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Young MD; Quotient Therapeutics Limited, Saffron Walden, UK., Mahbubani KTA; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Martin HC; Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK., Stratton MR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics Limited, Saffron Walden, UK., Rahbari R; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Martincorena I; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8089), pp. 411-420. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article; Twin Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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Early Cancer Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Young+MD%22">Young MD</searchLink>; Quotient Therapeutics Limited, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22Mahbubani+KTA%22">Mahbubani KTA</searchLink>; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Martin+HC%22">Martin HC</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.; Quotient Therapeutics Limited, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22Rahbari+R%22">Rahbari R</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Small+KS%22">Small KS</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Martincorena+I%22">Martincorena I</searchLink>; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.
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