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Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8.

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Title: Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8.
Authors: Roth A; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Lütke S; Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Biochemistry, Medical Faculty and University Hospital Cologne, Cologne, Germany., Mörgelin M; Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.; Colzyx AB, Lund, Sweden., Meinberger D; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Hermes G; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Sengle G; Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Biochemistry, Medical Faculty and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Koch M; Center for Biochemistry, Medical Faculty and University Hospital Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany.; Institute for Dental Research and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Drexelius M; Institute for Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany., Gebauer J; Institute for Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany., Neundorf I; Institute for Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany., Elezagic D; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Paulsson M; Center for Biochemistry, Medical Faculty and University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Streichert T; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Klatt AR; Institute for Clinical Chemistry, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2025 Sep 23; Vol. 15, pp. 1671738. Date of Electronic Publication: 2025 Sep 23 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8.
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