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General Anesthesia and Systemic Hyperosmolality Modulate Lumbar Intrathecal Drug Distribution in Female Rats.

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Title: General Anesthesia and Systemic Hyperosmolality Modulate Lumbar Intrathecal Drug Distribution in Female Rats.
Authors: Persson NDÅ; Individualized Drug Therapy Research Program and Department of Pharmacology, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Lohela TJ; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Department of Anaesthesiology, Intensive Care and Pain Medicine, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Anttila JE; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Mäkelä J; Individualized Drug Therapy Research Program, and Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Rosenholm M; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Peltoniemi M; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Jalonen SC; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., García-Horsman JA; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Sarparanta M; Department of Chemistry, Radiochemistry, University of Helsinki, Helsinki, Finland., Nedergaard M; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York., Rantamäki T; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, and SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lilius TO; Individualized Drug Therapy Research Program, and Department of Pharmacology, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Department of Emergency Medicine and Services, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Source: Anesthesiology [Anesthesiology] 2026 Feb 01; Vol. 144 (2), pp. 390-401. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1300217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1175 (Electronic) Linking ISSN: 00033022 NLM ISO Abbreviation: Anesthesiology Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Persson+NDÅ%22">Persson NDÅ</searchLink>; Individualized Drug Therapy Research Program and Department of Pharmacology, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lohela+TJ%22">Lohela TJ</searchLink>; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Department of Anaesthesiology, Intensive Care and Pain Medicine, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Anttila+JE%22">Anttila JE</searchLink>; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Mäkelä+J%22">Mäkelä J</searchLink>; Individualized Drug Therapy Research Program, and Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Rosenholm+M%22">Rosenholm M</searchLink>; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Peltoniemi+M%22">Peltoniemi M</searchLink>; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Jalonen+SC%22">Jalonen SC</searchLink>; Individualized Drug Therapy Research Program, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22García-Horsman+JA%22">García-Horsman JA</searchLink>; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sarparanta+M%22">Sarparanta M</searchLink>; Department of Chemistry, Radiochemistry, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Nedergaard+M%22">Nedergaard M</searchLink>; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York.<br /><searchLink fieldCode="AU" term="%22Rantamäki+T%22">Rantamäki T</searchLink>; Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, and SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lilius+TO%22">Lilius TO</searchLink>; Individualized Drug Therapy Research Program, and Department of Pharmacology, Faculty of Medicine, and Division of Pharmacology and Pharmacotherapy, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Department of Emergency Medicine and Services, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
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