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Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15-GFRaL-RET Complex Cell Signaling.

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Bibliographic Details
Title:	Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15-GFRaL-RET Complex Cell Signaling.
Authors:	Noisier AFM, Sandmark J, Edfeldt F, Backmark A, Broddefalk J, Wandzik J, Jurva U, Ek M, Johansson CA, Barlind L, Gunnarsson J, Bigalke JM, Xue Y, Frolov AI, Kankkonen C, Roth RG, Fritsch M, Watcham S; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., van Rietschoten K; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Mudd GE; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Harrison H; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Chen L; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Skynner MJ; BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K., Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Chankeshwara SV, Lemurell M
Source:	Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21441-21457. Date of Electronic Publication: 2025 Oct 09.
Publication Type:	Journal Article
Journal Info:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1520-4804
DOI:	10.1021/acs.jmedchem.5c01378