Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene.
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| Title: | Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene. |
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| Authors: | Oak N; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN., Chen W; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN.; Division of Computational Biology, Mayo Clinic, Rochester, MN., Blake A; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN., Harrison L; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN., O'Brien M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Previti C; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Balasubramanian G; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Maass K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Hirsch S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Human Genetics, Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., Penkert J; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schramm K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Nathrath M; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.; CCU Pediatric Oncol, German Cancer Research Center (DKFZ), Heidelberg, Germany., Dirksen U; Pediatrics III, West German Cancer Center University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK) Site Essen, Essen, Germany.; National Center for Tumor Diseases (NCT) Site Essen, Essen, Germany., Li J; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN., Sapkota Y; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN., Ness KK; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN., Guenther LM; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Kratz C; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Wang Z; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.; Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN., Armstrong GT; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN., Hudson MM; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN., Wu G; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN.; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN., Autry RJ; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Nichols KE; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN., Sharma R; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN.; Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children's, Cleaveland, OH. |
| Source: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Dec 20; Vol. 43 (36), pp. 3833-3843. Date of Electronic Publication: 2025 Oct 09. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41066719 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Oak+N%22">Oak N</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN.; Division of Computational Biology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Blake+A%22">Blake A</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Harrison+L%22">Harrison L</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22O'Brien+M%22">O'Brien M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Previti+C%22">Previti C</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Balasubramanian+G%22">Balasubramanian G</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maass+K%22">Maass K</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hirsch+S%22">Hirsch S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Human Genetics, Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Penkert+J%22">Penkert J</searchLink>; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+BC%22">Jones BC</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schramm+K%22">Schramm K</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nathrath+M%22">Nathrath M</searchLink>; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.; Department of Human Genetics, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Pajtler+KW%22">Pajtler KW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jones+DTW%22">Jones DTW</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.; CCU Pediatric Oncol, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dirksen+U%22">Dirksen U</searchLink>; Pediatrics III, West German Cancer Center University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK) Site Essen, Essen, Germany.; National Center for Tumor Diseases (NCT) Site Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Sapkota+Y%22">Sapkota Y</searchLink>; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Ness+KK%22">Ness KK</searchLink>; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Guenther+LM%22">Guenther LM</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Pfister+SM%22">Pfister SM</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kratz+C%22">Kratz C</searchLink>; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.; Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Armstrong+GT%22">Armstrong GT</searchLink>; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Hudson+MM%22">Hudson MM</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN.; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Autry+RJ%22">Autry RJ</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nichols+KE%22">Nichols KE</searchLink>; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN.; Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children's, Cleaveland, OH. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2025 Dec 20; Vol. 43 (36), pp. 3833-3843. <i>Date of Electronic Publication: </i>2025 Oct 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1200/JCO-25-01114 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 3833 Titles: – TitleFull: Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Oak N – PersonEntity: Name: NameFull: Chen W – PersonEntity: Name: NameFull: Blake A – PersonEntity: Name: NameFull: Harrison L – PersonEntity: Name: NameFull: O'Brien M – PersonEntity: Name: NameFull: Previti C – PersonEntity: Name: NameFull: Balasubramanian G – PersonEntity: Name: NameFull: Maass K – PersonEntity: Name: NameFull: Hirsch S – PersonEntity: Name: NameFull: Penkert J – PersonEntity: Name: NameFull: Jones BC – PersonEntity: Name: NameFull: Schramm K – PersonEntity: Name: NameFull: Nathrath M – PersonEntity: Name: NameFull: Pajtler KW – PersonEntity: Name: NameFull: Jones DTW – PersonEntity: Name: NameFull: Witt O – PersonEntity: Name: NameFull: Dirksen U – PersonEntity: Name: NameFull: Li J – PersonEntity: Name: NameFull: Sapkota Y – PersonEntity: Name: NameFull: Ness KK – PersonEntity: Name: NameFull: Guenther LM – PersonEntity: Name: NameFull: Pfister SM – PersonEntity: Name: NameFull: Kratz C – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Armstrong GT – PersonEntity: Name: NameFull: Hudson MM – PersonEntity: Name: NameFull: Wu G – PersonEntity: Name: NameFull: Autry RJ – PersonEntity: Name: NameFull: Nichols KE – PersonEntity: Name: NameFull: Sharma R IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 12 Text: 2025 Dec 20 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1527-7755 Numbering: – Type: volume Value: 43 – Type: issue Value: 36 Titles: – TitleFull: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Type: main |
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