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Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system.

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Title: Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system.
Authors: Edwards K; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Merrill SM; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA., Konwar C; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Jude MS; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Zhuang BC; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Meijer M; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Navarro-Delgado E; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., MacIsaac JL; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada., Mandhane P; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Simons E; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Moraes TJ; Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada., Azad MB; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Subbarao P; Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology & Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada., Bustamante M; ISGlobal, Institute of Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centro de Investigación en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Vrijheid M; ISGlobal, Institute of Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centro de Investigación en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Turvey S; BC Children's Hospital Research Institute Vancouver, Vancouver, BC, Canada., Kobor MS; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; BC Children's Hospital Research Institute Vancouver, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; Program in Child and Brain Development, CIFAR, Toronto, ON, Canada. Michael.kobor@ubc.ca.
Source: Communications biology [Commun Biol] 2025 Oct 09; Vol. 8 (1), pp. 1447. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system.
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  Data: <searchLink fieldCode="AU" term="%22Edwards+K%22">Edwards K</searchLink>; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Merrill+SM%22">Merrill SM</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Psychology, University of Massachusetts Lowell, Lowell, MA, USA.<br /><searchLink fieldCode="AU" term="%22Konwar+C%22">Konwar C</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Jude+MS%22">Jude MS</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Zhuang+BC%22">Zhuang BC</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Meijer+M%22">Meijer M</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Navarro-Delgado+E%22">Navarro-Delgado E</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22MacIsaac+JL%22">MacIsaac JL</searchLink>; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Mandhane+P%22">Mandhane P</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Simons+E%22">Simons E</searchLink>; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Moraes+TJ%22">Moraes TJ</searchLink>; Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Azad+MB%22">Azad MB</searchLink>; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Subbarao+P%22">Subbarao P</searchLink>; Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology & Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bustamante+M%22">Bustamante M</searchLink>; ISGlobal, Institute of Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centro de Investigación en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vrijheid+M%22">Vrijheid M</searchLink>; ISGlobal, Institute of Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Centro de Investigación en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Turvey+S%22">Turvey S</searchLink>; BC Children's Hospital Research Institute Vancouver, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Kobor+MS%22">Kobor MS</searchLink>; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; Edwin S.H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; BC Children's Hospital Research Institute Vancouver, Vancouver, BC, Canada. Michael.kobor@ubc.ca.; Program in Child and Brain Development, CIFAR, Toronto, ON, Canada. Michael.kobor@ubc.ca.
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