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Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study).

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Title: Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study).
Authors: Serrano-Villar S; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Medicine, Universidad Antonio de Nebrija, Madrid, Spain., Martín-Pedraza L; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain., Tiraboschi J; Department of Infectious Diseases, Hospital Universitario de Bellvitge, Barcelona, Spain., Novella M; Department of Internal Medicine, Hospital Universitario Príncipe de Asturias, Madrid, Spain., Cabello-Úbeda A; Division of Infectious Diseases, Health Research Institute-Fundación Jiménez Díaz University Hospital and Universidad Autónoma de Madrid(IIS-FJD, UAM), Madrid, Spain., López-Cortés L; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, Sevilla, Spain., Busca C; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Internal Medicine, Hospital Universitario La Paz and CIBERINFEC, Madrid, Spain., Torralba M; Department of Internal Medicine, Hospital Universitario de Guadalajara, Guadalajara, Spain., Crusells MJ; Department of Infectious Diseases, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Hidalgo-Tenorio C; Infectious Diseases Unit, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitario de Granada (IBS-Granada), Granada, Spain.; Instituto de Investigación Biosanitario de Granada (IBS) Granada, Spain., Estrada V; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Internal Medicine, Hospital Universitario Clínico San Carlos, IdiSSC and Universidad Complutense Madrid, Madrid, Spain., Del Amo-de Palacios A; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain., Díaz de Santiago A; Department of Internal Medicine, Hospital Universitario Puerta de Hierro, Madrid, Spain., Fons-Contreras M; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain., Santos J; Infectious Diseases Unit, Hospital Universitario Virgen de la Victoria de Málaga. IBIMA-Platafoma BIONAND Málaga, Spain., Bernal E; Infectious Diseases Unit, Hospital Universitario Reina Sofía de Murcia, Murcia, Spain., Montero-Alonso M; Infectious Diseases Unit, Hospital Universitario y Politécnico La Fé, Valencia, Spain., Troya J; Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain., Blanco JR; Department of Infectious Diseases, Hospital Universitario San Pedro-CIBIR, La Rioja, Spain., Burgos J; Department of Infectious Diseases, Hospital Vall D'Hebron, Barcelona, Spain., de Miguel M; Fundación SEIMC-GESIDA, Madrid, Spain., Moreno S; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Feb 25; Vol. 82 (2), pp. e262-e274.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase IV
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
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  Data: Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults With HIV (INSTINCT/GESIDA10918 Study).
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  Data: <searchLink fieldCode="AU" term="%22Serrano-Villar+S%22">Serrano-Villar S</searchLink>; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Medicine, Universidad Antonio de Nebrija, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martín-Pedraza+L%22">Martín-Pedraza L</searchLink>; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tiraboschi+J%22">Tiraboschi J</searchLink>; Department of Infectious Diseases, Hospital Universitario de Bellvitge, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Novella+M%22">Novella M</searchLink>; Department of Internal Medicine, Hospital Universitario Príncipe de Asturias, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cabello-Úbeda+A%22">Cabello-Úbeda A</searchLink>; Division of Infectious Diseases, Health Research Institute-Fundación Jiménez Díaz University Hospital and Universidad Autónoma de Madrid(IIS-FJD, UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Cortés+L%22">López-Cortés L</searchLink>; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Busca+C%22">Busca C</searchLink>; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Internal Medicine, Hospital Universitario La Paz and CIBERINFEC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Torralba+M%22">Torralba M</searchLink>; Department of Internal Medicine, Hospital Universitario de Guadalajara, Guadalajara, Spain.<br /><searchLink fieldCode="AU" term="%22Crusells+MJ%22">Crusells MJ</searchLink>; Department of Infectious Diseases, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Hidalgo-Tenorio+C%22">Hidalgo-Tenorio C</searchLink>; Infectious Diseases Unit, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitario de Granada (IBS-Granada), Granada, Spain.; Instituto de Investigación Biosanitario de Granada (IBS) Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Estrada+V%22">Estrada V</searchLink>; CIBER de Enfermedades Infecciosas, Madrid, Spain.; Department of Internal Medicine, Hospital Universitario Clínico San Carlos, IdiSSC and Universidad Complutense Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Amo-de+Palacios+A%22">Del Amo-de Palacios A</searchLink>; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz+de+Santiago+A%22">Díaz de Santiago A</searchLink>; Department of Internal Medicine, Hospital Universitario Puerta de Hierro, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fons-Contreras+M%22">Fons-Contreras M</searchLink>; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Santos+J%22">Santos J</searchLink>; Infectious Diseases Unit, Hospital Universitario Virgen de la Victoria de Málaga. IBIMA-Platafoma BIONAND Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Bernal+E%22">Bernal E</searchLink>; Infectious Diseases Unit, Hospital Universitario Reina Sofía de Murcia, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Montero-Alonso+M%22">Montero-Alonso M</searchLink>; Infectious Diseases Unit, Hospital Universitario y Politécnico La Fé, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Troya+J%22">Troya J</searchLink>; Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+JR%22">Blanco JR</searchLink>; Department of Infectious Diseases, Hospital Universitario San Pedro-CIBIR, La Rioja, Spain.<br /><searchLink fieldCode="AU" term="%22Burgos+J%22">Burgos J</searchLink>; Department of Infectious Diseases, Hospital Vall D'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22de+Miguel+M%22">de Miguel M</searchLink>; Fundación SEIMC-GESIDA, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno+S%22">Moreno S</searchLink>; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, and Universidad de Alcalá, Madrid, Spain.
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