Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset.
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| Title: | Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset. |
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| Authors: | Simpson-Yap S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Carlton, VIC, Australia.; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Morwitch E; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Tanner SA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, Australia., Thomson SM; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Eisner A; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Lea RA; Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Kelvin Grove, QLD, Australia.; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia., Kilpatrick TJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Lechner-Scott J; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia., Scott RJ; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia., Xavier A; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia., Maltby VE; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia., Lucas RM; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia., Taylor BV; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Lidbury BA; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia., Broadley SA; School of Medicine and Dentistry, Gold Coast Campus, Griffith University, Southport, QLD, Australia., van der Mei I; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Merid MW; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Novakovic B; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia., Saffery R; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia., Hedström AK; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Stridh P; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Jagodic M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Alfredsson L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Ponsonby AL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia. |
| Corporate Authors: | Ausimmune Investigator Group |
| Source: | Annals of neurology [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 341-355. Date of Electronic Publication: 2025 Oct 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41070760 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Simpson-Yap+S%22">Simpson-Yap S</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Carlton, VIC, Australia.; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.<br /><searchLink fieldCode="AU" term="%22Morwitch+E%22">Morwitch E</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tanner+SA%22">Tanner SA</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thomson+SM%22">Thomson SM</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Eisner+A%22">Eisner A</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lea+RA%22">Lea RA</searchLink>; Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Kelvin Grove, QLD, Australia.; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kilpatrick+TJ%22">Kilpatrick TJ</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lechner-Scott+J%22">Lechner-Scott J</searchLink>; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Scott+RJ%22">Scott RJ</searchLink>; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Xavier+A%22">Xavier A</searchLink>; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Maltby+VE%22">Maltby VE</searchLink>; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lucas+RM%22">Lucas RM</searchLink>; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+BV%22">Taylor BV</searchLink>; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.<br /><searchLink fieldCode="AU" term="%22Lidbury+BA%22">Lidbury BA</searchLink>; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Broadley+SA%22">Broadley SA</searchLink>; School of Medicine and Dentistry, Gold Coast Campus, Griffith University, Southport, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22van+der+Mei+I%22">van der Mei I</searchLink>; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.<br /><searchLink fieldCode="AU" term="%22Merid+MW%22">Merid MW</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Novakovic+B%22">Novakovic B</searchLink>; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Saffery+R%22">Saffery R</searchLink>; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hedström+AK%22">Hedström AK</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Stridh+P%22">Stridh P</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Olsson+T%22">Olsson T</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jagodic+M%22">Jagodic M</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Alfredsson+L%22">Alfredsson L</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Ponsonby+AL%22">Ponsonby AL</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Ausimmune+Investigator+Group%22">Ausimmune Investigator Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227707449%22">Annals of neurology</searchLink> [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 341-355. <i>Date of Electronic Publication: </i>2025 Oct 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7707449 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1531-8249 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203645134%22">03645134 </searchLink><i>NLM ISO Abbreviation: </i>Ann Neurol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41070760 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ana.78043 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 341 Titles: – TitleFull: Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Simpson-Yap S – PersonEntity: Name: NameFull: Morwitch E – PersonEntity: Name: NameFull: Tanner SA – PersonEntity: Name: NameFull: Thomson SM – PersonEntity: Name: NameFull: Eisner A – PersonEntity: Name: NameFull: Lea RA – PersonEntity: Name: NameFull: Kilpatrick TJ – PersonEntity: Name: NameFull: Lechner-Scott J – PersonEntity: Name: NameFull: Scott RJ – PersonEntity: Name: NameFull: Xavier A – PersonEntity: Name: NameFull: Maltby VE – PersonEntity: Name: NameFull: Lucas RM – PersonEntity: Name: NameFull: Taylor BV – PersonEntity: Name: NameFull: Lidbury BA – PersonEntity: Name: NameFull: Broadley SA – PersonEntity: Name: NameFull: van der Mei I – PersonEntity: Name: NameFull: Merid MW – PersonEntity: Name: NameFull: Novakovic B – PersonEntity: Name: NameFull: Saffery R – PersonEntity: Name: NameFull: Hedström AK – PersonEntity: Name: NameFull: Stridh P – PersonEntity: Name: NameFull: Olsson T – PersonEntity: Name: NameFull: Jagodic M – PersonEntity: Name: NameFull: Alfredsson L – PersonEntity: Name: NameFull: Ponsonby AL IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: 2026 Feb Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1531-8249 Numbering: – Type: volume Value: 99 – Type: issue Value: 2 Titles: – TitleFull: Annals of neurology Type: main |
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