Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset.
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| Title: | Epstein-Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset. |
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| Authors: | Simpson-Yap S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Neuroepidemiology Unit, Melbourne School of Population & Global Health, The University of Melbourne, Carlton, VIC, Australia.; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Morwitch E; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Tanner SA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, Australia., Thomson SM; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Eisner A; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Lea RA; Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Kelvin Grove, QLD, Australia.; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia., Kilpatrick TJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Lechner-Scott J; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia., Scott RJ; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia., Xavier A; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia., Maltby VE; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW, Australia., Lucas RM; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia., Taylor BV; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Lidbury BA; National Centre for Epidemiology and Population Health, The Australian National University, Acton, ACT, Australia., Broadley SA; School of Medicine and Dentistry, Gold Coast Campus, Griffith University, Southport, QLD, Australia., van der Mei I; MS Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Merid MW; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Novakovic B; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia., Saffery R; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Paediatrics, The Royal Children's Hospital, Parkville, VIC, Australia., Hedström AK; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Stridh P; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Jagodic M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Alfredsson L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Ponsonby AL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, The University of Melbourne, Parkville, VIC, Australia. |
| Corporate Authors: | Ausimmune Investigator Group |
| Source: | Annals of neurology [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 341-355. Date of Electronic Publication: 2025 Oct 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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