Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning.
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| Title: | Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning. |
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| Authors: | Du C; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Zhang Y; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Zhu W; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China., Liu X; Department of Laboratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China., Liu N; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China., He Z; Wuhan Center for Control & Prevention, Wuhan 430060, China., Liu J; Wuhan Center for Control & Prevention, Wuhan 430060, China., Lin Y; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China., Hu X; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China. |
| Source: | Analytical chemistry [Anal Chem] 2025 Oct 21; Vol. 97 (41), pp. 22817-22825. Date of Electronic Publication: 2025 Oct 10. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41071089 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Du+C%22">Du C</searchLink>; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Laboratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China.<br /><searchLink fieldCode="AU" term="%22Liu+N%22">Liu N</searchLink>; Department of Biomedical Engineering, College of Life Science and Techology, Huazhong University of Science and Technology, Wuhan 430016, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Wuhan Center for Control & Prevention, Wuhan 430060, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Wuhan Center for Control & Prevention, Wuhan 430060, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Chemistry, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220370536%22">Analytical chemistry</searchLink> [Anal Chem] 2025 Oct 21; Vol. 97 (41), pp. 22817-22825. <i>Date of Electronic Publication: </i>2025 Oct 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-6882 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200032700%22">00032700 </searchLink><i>NLM ISO Abbreviation: </i>Anal Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41071089 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.analchem.5c04501 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 22817 Titles: – TitleFull: Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Du C – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Zhu W – PersonEntity: Name: NameFull: Liu X – PersonEntity: Name: NameFull: Liu N – PersonEntity: Name: NameFull: He Z – PersonEntity: Name: NameFull: Liu J – PersonEntity: Name: NameFull: Lin Y – PersonEntity: Name: NameFull: Hu X IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 10 Text: 2025 Oct 21 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1520-6882 Numbering: – Type: volume Value: 97 – Type: issue Value: 41 Titles: – TitleFull: Analytical chemistry Type: main |
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