Silica nanoparticles trigger striatal oxidative stress, apoptosis, and histopathological alterations: in vivo and in silico molecular docking insights.

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Title: Silica nanoparticles trigger striatal oxidative stress, apoptosis, and histopathological alterations: in vivo and in silico molecular docking insights.
Authors: Boukholda K; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia. khadijaboukholdafss@gmail.com.; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain. khadijaboukholdafss@gmail.com.; Department of Neurobiology, Center for Neurotrauma, Multiomics and Biomarkers (CNMB), Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA. khadijaboukholdafss@gmail.com., Aouey B; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia., Chtourou Y; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia., Elbayoumi E; Department of Neurobiology, Center for Neurotrauma, Multiomics and Biomarkers (CNMB), Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA., Guerrero-Hue M; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain., García-Caballero C; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain., Boukholda F; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia., Vallejo-Mudarra M; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain., Sameem B; Bioengineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, 23000, Beni Mellal, Morocco., Chigr F; Complex Carbohydrate Research Center, University of Georgia, Athens, USA., Bouchard M; Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U436, Main Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada., Moreno JA; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain., Fetoui H; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
Source: Histochemistry and cell biology [Histochem Cell Biol] 2025 Oct 10; Vol. 163 (1), pp. 97. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Boukholda+K%22">Boukholda K</searchLink>; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia. khadijaboukholdafss@gmail.com.; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain. khadijaboukholdafss@gmail.com.; Department of Neurobiology, Center for Neurotrauma, Multiomics and Biomarkers (CNMB), Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA. khadijaboukholdafss@gmail.com.<br /><searchLink fieldCode="AU" term="%22Aouey+B%22">Aouey B</searchLink>; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.<br /><searchLink fieldCode="AU" term="%22Chtourou+Y%22">Chtourou Y</searchLink>; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.<br /><searchLink fieldCode="AU" term="%22Elbayoumi+E%22">Elbayoumi E</searchLink>; Department of Neurobiology, Center for Neurotrauma, Multiomics and Biomarkers (CNMB), Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Guerrero-Hue+M%22">Guerrero-Hue M</searchLink>; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22García-Caballero+C%22">García-Caballero C</searchLink>; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Boukholda+F%22">Boukholda F</searchLink>; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.<br /><searchLink fieldCode="AU" term="%22Vallejo-Mudarra+M%22">Vallejo-Mudarra M</searchLink>; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Sameem+B%22">Sameem B</searchLink>; Bioengineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, 23000, Beni Mellal, Morocco.<br /><searchLink fieldCode="AU" term="%22Chigr+F%22">Chigr F</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, USA.<br /><searchLink fieldCode="AU" term="%22Bouchard+M%22">Bouchard M</searchLink>; Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U436, Main Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Moreno+JA%22">Moreno JA</searchLink>; Department of Cell Biology, Physiology and Immunology, University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, 14004, Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Fetoui+H%22">Fetoui H</searchLink>; Laboratory of Toxicology-Microbiology and Environmental Health (17ES06), Life Science Department, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
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