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Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization.

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Title: Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization.
Authors: Malladi SK; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Jaiswal D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ying B; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Alsoussi WB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Darling TL; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Dadonaite B; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA., Civljak A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Horvath SC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Zhou JQ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kim W; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Microbiology, Korea University College of Medicine, Seoul, Korea., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Han F; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Scheaffer SM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Farnsworth CW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Nachbagauer R; Moderna Inc., Cambridge, MA, USA., Nestorova B; Moderna Inc., Cambridge, MA, USA., Chalkias S; Moderna Inc., Cambridge, MA, USA., Klebert MK; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Edwards DK; Moderna Inc., Cambridge, MA, USA., Paris R; Moderna Inc., Cambridge, MA, USA., Strnad BS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Middleton WD; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., O'Halloran JA; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Center for Experimental Pathogen Host Research, University College Dublin, Dublin, Ireland., Presti RM; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Boon ACM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Diamond MS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Bajic G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.
Source: Science immunology [Sci Immunol] 2025 Oct 17; Vol. 10 (112), pp. eadu4107. Date of Electronic Publication: 2025 Oct 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization.
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  Data: <searchLink fieldCode="AU" term="%22Malladi+SK%22">Malladi SK</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Jaiswal+D%22">Jaiswal D</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ying+B%22">Ying B</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Alsoussi+WB%22">Alsoussi WB</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Darling+TL%22">Darling TL</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dadonaite+B%22">Dadonaite B</searchLink>; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Civljak+A%22">Civljak A</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Horvath+SC%22">Horvath SC</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+JQ%22">Zhou JQ</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Microbiology, Korea University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Turner+JS%22">Turner JS</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Schmitz+AJ%22">Schmitz AJ</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Han+F%22">Han F</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Scheaffer+SM%22">Scheaffer SM</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Farnsworth+CW%22">Farnsworth CW</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Nachbagauer+R%22">Nachbagauer R</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nestorova+B%22">Nestorova B</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chalkias+S%22">Chalkias S</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Klebert+MK%22">Klebert MK</searchLink>; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+DK%22">Edwards DK</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Paris+R%22">Paris R</searchLink>; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Strnad+BS%22">Strnad BS</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Middleton+WD%22">Middleton WD</searchLink>; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22O'Halloran+JA%22">O'Halloran JA</searchLink>; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Center for Experimental Pathogen Host Research, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Presti+RM%22">Presti RM</searchLink>; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bloom+JD%22">Bloom JD</searchLink>; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Boon+ACM%22">Boon ACM</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+MS%22">Diamond MS</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; 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Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bajic+G%22">Bajic G</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ellebedy+AH%22">Ellebedy AH</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.
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