Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma.

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Bibliographic Details
Title: Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma.
Authors: Di Meo F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Albano F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Cesarano A; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Wang Y; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kale B; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Shain K; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Silva A; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kurihara N; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Tenshin H; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Jellyman D; Antibody Technology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Song X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Ghaffari S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Mesa H; Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA., Creelan B; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Freeman C; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Zhao X; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Meads MB; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Marino S; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Locke F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Hwu P; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Roodman D; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Mansilla-Soto J; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Perna F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: fabiana.perna@moffitt.org.
Source: Cancer cell [Cancer Cell] 2025 Dec 08; Vol. 43 (12), pp. 2298-2310.e6. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-3686
DOI:10.1016/j.ccell.2025.09.007