Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma.

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Title: Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma.
Authors: Di Meo F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Albano F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Cesarano A; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Wang Y; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kale B; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Shain K; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Silva A; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kurihara N; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Tenshin H; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Jellyman D; Antibody Technology, Fred Hutchinson Cancer Center, Seattle, WA, USA., Song X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Ghaffari S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Mesa H; Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA., Creelan B; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Freeman C; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Zhao X; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Meads MB; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Marino S; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Locke F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Hwu P; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Roodman D; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Mansilla-Soto J; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Perna F; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: fabiana.perna@moffitt.org.
Source: Cancer cell [Cancer Cell] 2025 Dec 08; Vol. 43 (12), pp. 2298-2310.e6. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
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  Data: Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Di+Meo+F%22">Di Meo F</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Albano+F%22">Albano F</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cesarano+A%22">Cesarano A</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kale+B%22">Kale B</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Shain+K%22">Shain K</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Silva+A%22">Silva A</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kurihara+N%22">Kurihara N</searchLink>; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Tenshin+H%22">Tenshin H</searchLink>; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Jellyman+D%22">Jellyman D</searchLink>; Antibody Technology, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ghaffari+S%22">Ghaffari S</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mesa+H%22">Mesa H</searchLink>; Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Creelan+B%22">Creelan B</searchLink>; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+C%22">Freeman C</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Meads+MB%22">Meads MB</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+PC%22">Rodriguez PC</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Marino+S%22">Marino S</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Locke+F%22">Locke F</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+P%22">Hwu P</searchLink>; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Roodman+D%22">Roodman D</searchLink>; Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Mansilla-Soto+J%22">Mansilla-Soto J</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Perna+F%22">Perna F</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Department of Bioengineering, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: fabiana.perna@moffitt.org.
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  Data: <searchLink fieldCode="JN" term="%22101130617%22">Cancer cell</searchLink> [Cancer Cell] 2025 Dec 08; Vol. 43 (12), pp. 2298-2310.e6. <i>Date of Electronic Publication: </i>2025 Oct 09.
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