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Digital pharmacological twins: Bridging multi-scale modelling and artificial intelligence for precision medicine: The DIGPHAT consortium.

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Title: Digital pharmacological twins: Bridging multi-scale modelling and artificial intelligence for precision medicine: The DIGPHAT consortium.
Authors: Woillard JB; Pharmacology and Transplantation, Inserm U1248, University of Limoges, 87000 Limoges, France; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), 87000 Limoges, France. Electronic address: jean-baptiste.woillard@unilim.fr., Benzekry S; COMPutational Pharmacology and Clinical Oncology Department, Inria Sophia Antipolis - Méditerranée, Cancer Research Center of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University UM105, 13000 Marseille, France., Josse J; Premedical team Inria- Inserm (Idesp), University of Montpellier, 34000 Montpellier, France., White-Koning M; Univ Toulouse, Inserm, CRCT, 31000 Toulouse, France., Chatelut E; Univ Toulouse, Inserm, CRCT, 31000 Toulouse, France., Comets E; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France., Lemaitre F; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France., Franck B; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France., Gregoire M; Service de Pharmacologie Clinique, Nantes Université, CHU de Nantes, 44000 Nantes, France; Nantes Université, CHU de Nantes, Cibles et médicaments des infections et de l'immunité, IICiMed, UR 1155, 44000 Nantes, France., Stanke-Labesque F; University Grenoble Alpes, Inserm 1300- HP2, CHU de Grenoble Alpes, 38000 Grenoble, France., Zohar S; Inserm, UMRS 1346, Université Paris Cité, Inria, HeKA, 75000 Paris, France., Ursino M; Inserm, UMRS 1346, Université Paris Cité, Inria, HeKA, 75000 Paris, France., Battail C; University Grenoble Alpes, IRIG, Laboratoire Biosciences et Bioingénierie pour la Santé, UA 13 Inserm-CEA-UGA, 38000 Grenoble, France.
Corporate Authors: DIGPHAT consortium
Source: Therapie [Therapie] 2026 Mar-Apr; Vol. 81 (2), pp. 147-158. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Masson Country of Publication: France NLM ID: 0420544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5578 (Electronic) Linking ISSN: 00405957 NLM ISO Abbreviation: Therapie Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Woillard+JB%22">Woillard JB</searchLink>; Pharmacology and Transplantation, Inserm U1248, University of Limoges, 87000 Limoges, France; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), 87000 Limoges, France. Electronic address: jean-baptiste.woillard@unilim.fr.<br /><searchLink fieldCode="AU" term="%22Benzekry+S%22">Benzekry S</searchLink>; COMPutational Pharmacology and Clinical Oncology Department, Inria Sophia Antipolis - Méditerranée, Cancer Research Center of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University UM105, 13000 Marseille, France.<br /><searchLink fieldCode="AU" term="%22Josse+J%22">Josse J</searchLink>; Premedical team Inria- Inserm (Idesp), University of Montpellier, 34000 Montpellier, France.<br /><searchLink fieldCode="AU" term="%22White-Koning+M%22">White-Koning M</searchLink>; Univ Toulouse, Inserm, CRCT, 31000 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Chatelut+E%22">Chatelut E</searchLink>; Univ Toulouse, Inserm, CRCT, 31000 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Comets+E%22">Comets E</searchLink>; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Lemaitre+F%22">Lemaitre F</searchLink>; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Franck+B%22">Franck B</searchLink>; Department of Clinical and Biological Pharmacology and Pharmacovigilance, Clinical Investigation Center CIC-P 1414, 35000 Rennes, France; University of Rennes, Centre Hospitalier Universitaire Rennes, École des Hautes Études en Santé Publique, IRSET (Institut de Recherche en Santé, Environnement et Travail), UMR S 1085, 35000 Rennes, France.<br /><searchLink fieldCode="AU" term="%22Gregoire+M%22">Gregoire M</searchLink>; Service de Pharmacologie Clinique, Nantes Université, CHU de Nantes, 44000 Nantes, France; Nantes Université, CHU de Nantes, Cibles et médicaments des infections et de l'immunité, IICiMed, UR 1155, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Stanke-Labesque+F%22">Stanke-Labesque F</searchLink>; University Grenoble Alpes, Inserm 1300- HP2, CHU de Grenoble Alpes, 38000 Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Zohar+S%22">Zohar S</searchLink>; Inserm, UMRS 1346, Université Paris Cité, Inria, HeKA, 75000 Paris, France.<br /><searchLink fieldCode="AU" term="%22Ursino+M%22">Ursino M</searchLink>; Inserm, UMRS 1346, Université Paris Cité, Inria, HeKA, 75000 Paris, France.<br /><searchLink fieldCode="AU" term="%22Battail+C%22">Battail C</searchLink>; University Grenoble Alpes, IRIG, Laboratoire Biosciences et Bioingénierie pour la Santé, UA 13 Inserm-CEA-UGA, 38000 Grenoble, France.
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