View in EDS

Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab.

Saved in:
Bibliographic Details
Title: Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab.
Authors: Pirrone C; Medical Oncology, S. Corona Hospital, Pietra Ligure (Savona), Italy; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Malapelle U; Department of Public Health, University Federico II, Naples 80131, Italy., Pepe F; Department of Public Health, University Federico II, Naples 80131, Italy., Lo Prinzi F; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma 200 - 00128, Italy., Nichetti F; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Saborowski A; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Antonuzzo L; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy., Camera S; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Satake T; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Peeters F; Digestive Oncology, University Hospitals Leuven, Leuven, Belgium., Vivaldi C; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Pressiani T; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Lucchetti J; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma 200 - 00128, Italy., Kim JW; Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea., Abidoye O; Department of Internal Medicine, Mayo ClinicPhoenix, AZ, USA., Rapposelli IG; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Tamberi S; Medical Oncology, Santa Maria delle Croci hospital, Ravenna AUSL Romagna, ITALY., Finkelmeier F; Medical Clinic 1, Department of Gastroenterology, University Hospital Frankfur, Frankfurt am Main, Germany., Giordano G; Unit of Medical Oncology and Biomolecular Therapy, Policlinico Riuniti, Foggia, Italy; Department of Medical and Surgical Sciences, University of Foggia, Italy., Pircher C; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Chon HJ; Division of Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea., Braconi C; University of Glasgow (School of Cancer Sciences), Beatson West of Scotland Cancer Centre, CRUK Scotland Centre, Scotland., Qaisar A; University of Glasgow (School of Cancer Sciences), Beatson West of Scotland Cancer Centre, CRUK Scotland Centre, Scotland., Pastorino A; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Castet F; Gastrointestinal and Endocrine Tumor Unit, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Tamburini E; Oncology Department and Palliative Care, Cardinale Panico Tricase City Hospital, Tricase 73039, Italy., Yoo C; ASAN Medical Center, University of Ulsan College of Medicine, South Korea., Parisi A; Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria delle Marche, Via Conca 71, Ancona 60126, Italy., Diana A; Oncology Unit, Ospedale del Mare, Napoli, Italy., Scartozzi M; Medical Oncology, University and University Hospital, Cagliari, Italy., Prager GW; Department of Medicine I, Clinical Division of Oncology, Medical University Vienna, Austria., Avallone A; Clinical Experimental Abdominal Oncology Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Corallo S; Medical Oncology Unit, IRCCS Policlinico San Matteo, Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy., Schirripa M; Medical Oncology Unit, Department of Oncology and Hematology, Belcolle Hospital, Viterbo, Italy., Kim IH; Division of Oncology, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea., Perkhofer L; Internal Medicine 1, University Hospital Ulm, Ulm, Germany; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Oneda E; Dipartimento di Oncologia medica, Fondazione Poliambulanza, Brescia, Italy., Verrico M; UOC Oncologia A, Department of Hematology, Oncology and Dermatology, Policlinico Umberto I University Hospital, Sapienza University o f Rome, Viale Regina Elena, 324, Rome 00161, Italy., Adeva J; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Chan SL; State Key Laboratory of Translational Oncology, Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China., Spinelli GP; UOC Oncologia Territoriale, Polo Pontino, La Sapienza Università Di Roma, Latina, Italy., Personeni N; Medical Oncology Unit, P.O. Manerbio - ASST Garda, 25025 Manerbio, Brescia, Italy., Garajova I; Medical Oncology Unit, University Hospital of Parma, Parma 43126, Italy., Rodriquenz MG; Oncology Unit, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy., Leo S; Division of Oncology, Vito Fazzi Hospital, Lecce, Italy., Alvim CM; Medical Oncology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon 1649-035, Portugal., Roque R; Portuguese Institute of Oncology of Coimbra, Coimbra 3000-075, Portugal., Farinea G; Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy., Salani F; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., De Grandis C; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Lavacchi D; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Persano M; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Dekervel J; Digestive Oncology, University Hospitals Leuven, Leuven, Belgium., Niger M; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Balsano R; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy., Tonini G; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Roma 21 - 00128, Italy., Kang M; Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea., Bekaii-Saab T; Department of Internal Medicine, Mayo ClinicPhoenix, AZ, USA., Esposito L; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Boccaccino A; Medical Oncology, Santa Maria delle Croci hospital, Ravenna AUSL Romagna, ITALY., Himmelsbach V; Medical Clinic 1, Department of Gastroenterology, University Hospital Frankfur, Frankfurt am Main, Germany., Landriscina M; Unit of Medical Oncology and Biomolecular Therapy, Policlinico Riuniti, Foggia, Italy; Department of Medical and Surgical Sciences, University of Foggia, Italy., De Cobelli F; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Ratti F; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Daniel F; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Tesini G; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy., Masi G; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Vogel A; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Longo Family Chair in Liver Cancer Research, Division of Gastroenterology and Hepatology, Toronto General Hospital, Medical Oncology, Princess Margaret Cancer Centre, Schwartz Reisman Liver Research Centre, TorontoCanada., Lonardi S; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy., Rimini M; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Fornaro L; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. Electronic address: lorenzo.fornaro@gmail.com., Rimassa L; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy. Electronic address: lorenza.rimassa@hunimed.eu., Casadei-Gardini A; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy. Electronic address: casadeigardini@gmail.com.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Nov 17; Vol. 230, pp. 116035. Date of Electronic Publication: 2025 Oct 03.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41076988
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pirrone+C%22">Pirrone C</searchLink>; Medical Oncology, S. Corona Hospital, Pietra Ligure (Savona), Italy; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Malapelle+U%22">Malapelle U</searchLink>; Department of Public Health, University Federico II, Naples 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Pepe+F%22">Pepe F</searchLink>; Department of Public Health, University Federico II, Naples 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Prinzi+F%22">Lo Prinzi F</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma 200 - 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Nichetti+F%22">Nichetti F</searchLink>; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Saborowski+A%22">Saborowski A</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Antonuzzo+L%22">Antonuzzo L</searchLink>; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Camera+S%22">Camera S</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Satake+T%22">Satake T</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Peeters+F%22">Peeters F</searchLink>; Digestive Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vivaldi+C%22">Vivaldi C</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Pressiani+T%22">Pressiani T</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lucchetti+J%22">Lucchetti J</searchLink>; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma 200 - 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Kim+JW%22">Kim JW</searchLink>; Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Abidoye+O%22">Abidoye O</searchLink>; Department of Internal Medicine, Mayo ClinicPhoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Rapposelli+IG%22">Rapposelli IG</searchLink>; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Tamberi+S%22">Tamberi S</searchLink>; Medical Oncology, Santa Maria delle Croci hospital, Ravenna AUSL Romagna, ITALY.<br /><searchLink fieldCode="AU" term="%22Finkelmeier+F%22">Finkelmeier F</searchLink>; Medical Clinic 1, Department of Gastroenterology, University Hospital Frankfur, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Giordano+G%22">Giordano G</searchLink>; Unit of Medical Oncology and Biomolecular Therapy, Policlinico Riuniti, Foggia, Italy; Department of Medical and Surgical Sciences, University of Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Pircher+C%22">Pircher C</searchLink>; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Chon+HJ%22">Chon HJ</searchLink>; Division of Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.<br /><searchLink fieldCode="AU" term="%22Braconi+C%22">Braconi C</searchLink>; University of Glasgow (School of Cancer Sciences), Beatson West of Scotland Cancer Centre, CRUK Scotland Centre, Scotland.<br /><searchLink fieldCode="AU" term="%22Qaisar+A%22">Qaisar A</searchLink>; University of Glasgow (School of Cancer Sciences), Beatson West of Scotland Cancer Centre, CRUK Scotland Centre, Scotland.<br /><searchLink fieldCode="AU" term="%22Pastorino+A%22">Pastorino A</searchLink>; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Castet+F%22">Castet F</searchLink>; Gastrointestinal and Endocrine Tumor Unit, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tamburini+E%22">Tamburini E</searchLink>; Oncology Department and Palliative Care, Cardinale Panico Tricase City Hospital, Tricase 73039, Italy.<br /><searchLink fieldCode="AU" term="%22Yoo+C%22">Yoo C</searchLink>; ASAN Medical Center, University of Ulsan College of Medicine, South Korea.<br /><searchLink fieldCode="AU" term="%22Parisi+A%22">Parisi A</searchLink>; Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria delle Marche, Via Conca 71, Ancona 60126, Italy.<br /><searchLink fieldCode="AU" term="%22Diana+A%22">Diana A</searchLink>; Oncology Unit, Ospedale del Mare, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Scartozzi+M%22">Scartozzi M</searchLink>; Medical Oncology, University and University Hospital, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Prager+GW%22">Prager GW</searchLink>; Department of Medicine I, Clinical Division of Oncology, Medical University Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Avallone+A%22">Avallone A</searchLink>; Clinical Experimental Abdominal Oncology Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Corallo+S%22">Corallo S</searchLink>; Medical Oncology Unit, IRCCS Policlinico San Matteo, Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Schirripa+M%22">Schirripa M</searchLink>; Medical Oncology Unit, Department of Oncology and Hematology, Belcolle Hospital, Viterbo, Italy.<br /><searchLink fieldCode="AU" term="%22Kim+IH%22">Kim IH</searchLink>; Division of Oncology, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Perkhofer+L%22">Perkhofer L</searchLink>; Internal Medicine 1, University Hospital Ulm, Ulm, Germany; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Oneda+E%22">Oneda E</searchLink>; Dipartimento di Oncologia medica, Fondazione Poliambulanza, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Verrico+M%22">Verrico M</searchLink>; UOC Oncologia A, Department of Hematology, Oncology and Dermatology, Policlinico Umberto I University Hospital, Sapienza University o f Rome, Viale Regina Elena, 324, Rome 00161, Italy.<br /><searchLink fieldCode="AU" term="%22Adeva+J%22">Adeva J</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Chan+SL%22">Chan SL</searchLink>; State Key Laboratory of Translational Oncology, Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Spinelli+GP%22">Spinelli GP</searchLink>; UOC Oncologia Territoriale, Polo Pontino, La Sapienza Università Di Roma, Latina, Italy.<br /><searchLink fieldCode="AU" term="%22Personeni+N%22">Personeni N</searchLink>; Medical Oncology Unit, P.O. Manerbio - ASST Garda, 25025 Manerbio, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Garajova+I%22">Garajova I</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma 43126, Italy.<br /><searchLink fieldCode="AU" term="%22Rodriquenz+MG%22">Rodriquenz MG</searchLink>; Oncology Unit, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy.<br /><searchLink fieldCode="AU" term="%22Leo+S%22">Leo S</searchLink>; Division of Oncology, Vito Fazzi Hospital, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Alvim+CM%22">Alvim CM</searchLink>; Medical Oncology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon 1649-035, Portugal.<br /><searchLink fieldCode="AU" term="%22Roque+R%22">Roque R</searchLink>; Portuguese Institute of Oncology of Coimbra, Coimbra 3000-075, Portugal.<br /><searchLink fieldCode="AU" term="%22Farinea+G%22">Farinea G</searchLink>; Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Salani+F%22">Salani F</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22De+Grandis+C%22">De Grandis C</searchLink>; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Lavacchi+D%22">Lavacchi D</searchLink>; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Persano+M%22">Persano M</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ikeda+M%22">Ikeda M</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Dekervel+J%22">Dekervel J</searchLink>; Digestive Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Niger+M%22">Niger M</searchLink>; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Balsano+R%22">Balsano R</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tonini+G%22">Tonini G</searchLink>; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Roma 21 - 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bekaii-Saab+T%22">Bekaii-Saab T</searchLink>; Department of Internal Medicine, Mayo ClinicPhoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Esposito+L%22">Esposito L</searchLink>; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Boccaccino+A%22">Boccaccino A</searchLink>; Medical Oncology, Santa Maria delle Croci hospital, Ravenna AUSL Romagna, ITALY.<br /><searchLink fieldCode="AU" term="%22Himmelsbach+V%22">Himmelsbach V</searchLink>; Medical Clinic 1, Department of Gastroenterology, University Hospital Frankfur, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Landriscina+M%22">Landriscina M</searchLink>; Unit of Medical Oncology and Biomolecular Therapy, Policlinico Riuniti, Foggia, Italy; Department of Medical and Surgical Sciences, University of Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22De+Cobelli+F%22">De Cobelli F</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ratti+F%22">Ratti F</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Daniel+F%22">Daniel F</searchLink>; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Tesini+G%22">Tesini G</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Masi+G%22">Masi G</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Vogel+A%22">Vogel A</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany; Longo Family Chair in Liver Cancer Research, Division of Gastroenterology and Hepatology, Toronto General Hospital, Medical Oncology, Princess Margaret Cancer Centre, Schwartz Reisman Liver Research Centre, TorontoCanada.<br /><searchLink fieldCode="AU" term="%22Lonardi+S%22">Lonardi S</searchLink>; Department of Medical Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Rimini+M%22">Rimini M</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fornaro+L%22">Fornaro L</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. Electronic address: lorenzo.fornaro@gmail.com.<br /><searchLink fieldCode="AU" term="%22Rimassa+L%22">Rimassa L</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy. Electronic address: lorenza.rimassa@hunimed.eu.<br /><searchLink fieldCode="AU" term="%22Casadei-Gardini+A%22">Casadei-Gardini A</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy. Electronic address: casadeigardini@gmail.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2025 Nov 17; Vol. 230, pp. 116035. <i>Date of Electronic Publication: </i>2025 Oct 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41076988
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ejca.2025.116035
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 116035
    Titles:
      – TitleFull: Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pirrone C
      – PersonEntity:
          Name:
            NameFull: Malapelle U
      – PersonEntity:
          Name:
            NameFull: Pepe F
      – PersonEntity:
          Name:
            NameFull: Lo Prinzi F
      – PersonEntity:
          Name:
            NameFull: Nichetti F
      – PersonEntity:
          Name:
            NameFull: Saborowski A
      – PersonEntity:
          Name:
            NameFull: Antonuzzo L
      – PersonEntity:
          Name:
            NameFull: Camera S
      – PersonEntity:
          Name:
            NameFull: Satake T
      – PersonEntity:
          Name:
            NameFull: Peeters F
      – PersonEntity:
          Name:
            NameFull: Vivaldi C
      – PersonEntity:
          Name:
            NameFull: Pressiani T
      – PersonEntity:
          Name:
            NameFull: Lucchetti J
      – PersonEntity:
          Name:
            NameFull: Kim JW
      – PersonEntity:
          Name:
            NameFull: Abidoye O
      – PersonEntity:
          Name:
            NameFull: Rapposelli IG
      – PersonEntity:
          Name:
            NameFull: Tamberi S
      – PersonEntity:
          Name:
            NameFull: Finkelmeier F
      – PersonEntity:
          Name:
            NameFull: Giordano G
      – PersonEntity:
          Name:
            NameFull: Pircher C
      – PersonEntity:
          Name:
            NameFull: Chon HJ
      – PersonEntity:
          Name:
            NameFull: Braconi C
      – PersonEntity:
          Name:
            NameFull: Qaisar A
      – PersonEntity:
          Name:
            NameFull: Pastorino A
      – PersonEntity:
          Name:
            NameFull: Castet F
      – PersonEntity:
          Name:
            NameFull: Tamburini E
      – PersonEntity:
          Name:
            NameFull: Yoo C
      – PersonEntity:
          Name:
            NameFull: Parisi A
      – PersonEntity:
          Name:
            NameFull: Diana A
      – PersonEntity:
          Name:
            NameFull: Scartozzi M
      – PersonEntity:
          Name:
            NameFull: Prager GW
      – PersonEntity:
          Name:
            NameFull: Avallone A
      – PersonEntity:
          Name:
            NameFull: Corallo S
      – PersonEntity:
          Name:
            NameFull: Schirripa M
      – PersonEntity:
          Name:
            NameFull: Kim IH
      – PersonEntity:
          Name:
            NameFull: Perkhofer L
      – PersonEntity:
          Name:
            NameFull: Oneda E
      – PersonEntity:
          Name:
            NameFull: Verrico M
      – PersonEntity:
          Name:
            NameFull: Adeva J
      – PersonEntity:
          Name:
            NameFull: Chan SL
      – PersonEntity:
          Name:
            NameFull: Spinelli GP
      – PersonEntity:
          Name:
            NameFull: Personeni N
      – PersonEntity:
          Name:
            NameFull: Garajova I
      – PersonEntity:
          Name:
            NameFull: Rodriquenz MG
      – PersonEntity:
          Name:
            NameFull: Leo S
      – PersonEntity:
          Name:
            NameFull: Alvim CM
      – PersonEntity:
          Name:
            NameFull: Roque R
      – PersonEntity:
          Name:
            NameFull: Farinea G
      – PersonEntity:
          Name:
            NameFull: Salani F
      – PersonEntity:
          Name:
            NameFull: De Grandis C
      – PersonEntity:
          Name:
            NameFull: Lavacchi D
      – PersonEntity:
          Name:
            NameFull: Persano M
      – PersonEntity:
          Name:
            NameFull: Ikeda M
      – PersonEntity:
          Name:
            NameFull: Dekervel J
      – PersonEntity:
          Name:
            NameFull: Niger M
      – PersonEntity:
          Name:
            NameFull: Balsano R
      – PersonEntity:
          Name:
            NameFull: Tonini G
      – PersonEntity:
          Name:
            NameFull: Kang M
      – PersonEntity:
          Name:
            NameFull: Bekaii-Saab T
      – PersonEntity:
          Name:
            NameFull: Esposito L
      – PersonEntity:
          Name:
            NameFull: Boccaccino A
      – PersonEntity:
          Name:
            NameFull: Himmelsbach V
      – PersonEntity:
          Name:
            NameFull: Landriscina M
      – PersonEntity:
          Name:
            NameFull: De Cobelli F
      – PersonEntity:
          Name:
            NameFull: Ratti F
      – PersonEntity:
          Name:
            NameFull: Daniel F
      – PersonEntity:
          Name:
            NameFull: Tesini G
      – PersonEntity:
          Name:
            NameFull: Masi G
      – PersonEntity:
          Name:
            NameFull: Vogel A
      – PersonEntity:
          Name:
            NameFull: Lonardi S
      – PersonEntity:
          Name:
            NameFull: Rimini M
      – PersonEntity:
          Name:
            NameFull: Fornaro L
      – PersonEntity:
          Name:
            NameFull: Rimassa L
      – PersonEntity:
          Name:
            NameFull: Casadei-Gardini A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 11
              Text: 2025 Nov 17
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1879-0852
          Numbering:
            – Type: volume
              Value: 230
          Titles:
            – TitleFull: European journal of cancer (Oxford, England : 1990)
              Type: main
ResultId 1