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Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

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Title: Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.
Authors: Giamarellos-Bourboulis EJ; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Jemec GBE; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark., Prens EP; Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands., Riedemann NC; InflaRx GmbH, Jena, Germany., Otto I; InflaRx GmbH, Jena, Germany., Weisman J; Medical Dermatology Specialists, Sandy Springs, Atlanta, GA, USA., Pulka G; Centrum Medyczne All-Med, Krakòw, Poland., Nowicki RJ; Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, University Clinical Centre, Gdańsk, Poland., Kantardjiev V; Dermatology and Venereology Department, Military Medical Academy, Sofia, Bulgaria., Pinter A; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt/Main, Frankfurt/Main, Germany., Thomsen SF; Department of Dermatology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., Berneman D; University of Cincinnati, Department of Dermatology, Cincinnati, OH, USA., Kanni T; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Alavi A; Department of Dermatology, Mayo Clinic Rochester, Rochester, MN, USA., Breno B; CHU Nantes, Hôtel Dieu, Nantes, France., Gooderham M; SKiN Centre for Dermatology, Peterborough, ON, Canada.; Department of Medicine, Queen's University, Kingston, ON, Canada., Stone M; Shenandoah Medical Center, Shenandoah, IA, USA., Anadkat MJ; Department of Medicine, Division of Dermatology, Washington University, St. Louis, MO, USA., Katoulis A; 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Papakonstantis M; Department of Dermatology, 401 General Military Hospital of Athens, Athens, Greece., Becherel PA; Department of Dermatology, Antony Private Hospital, Antony, France., Szepietowski JC; Faculty of Medicine, Wrocław University of Science and Technology, Wrocław, Poland.; Department of Dermatovenereology, 4th Military Hospital, Wrocław, Poland., van der Zee HH; Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands., Zouboulis CC; Departments of Dermatology, Venereology, Allergology and Immunology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany., Sayed CJ; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.
Source: The British journal of dermatology [Br J Dermatol] 2026 Jan 27; Vol. 194 (2), pp. 254-263.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0004041 Publication Model: Print Cited Medium: Internet ISSN: 1365-2133 (Electronic) Linking ISSN: 00070963 NLM ISO Abbreviation: Br J Dermatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.
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  Data: <searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Jemec+GBE%22">Jemec GBE</searchLink>; Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Prens+EP%22">Prens EP</searchLink>; Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Riedemann+NC%22">Riedemann NC</searchLink>; InflaRx GmbH, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Otto+I%22">Otto I</searchLink>; InflaRx GmbH, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Weisman+J%22">Weisman J</searchLink>; Medical Dermatology Specialists, Sandy Springs, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Pulka+G%22">Pulka G</searchLink>; Centrum Medyczne All-Med, Krakòw, Poland.<br /><searchLink fieldCode="AU" term="%22Nowicki+RJ%22">Nowicki RJ</searchLink>; Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, University Clinical Centre, Gdańsk, Poland.<br /><searchLink fieldCode="AU" term="%22Kantardjiev+V%22">Kantardjiev V</searchLink>; Dermatology and Venereology Department, Military Medical Academy, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Pinter+A%22">Pinter A</searchLink>; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt/Main, Frankfurt/Main, Germany.<br /><searchLink fieldCode="AU" term="%22Thomsen+SF%22">Thomsen SF</searchLink>; Department of Dermatology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Berneman+D%22">Berneman D</searchLink>; University of Cincinnati, Department of Dermatology, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kanni+T%22">Kanni T</searchLink>; 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Alavi+A%22">Alavi A</searchLink>; Department of Dermatology, Mayo Clinic Rochester, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Breno+B%22">Breno B</searchLink>; CHU Nantes, Hôtel Dieu, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Gooderham+M%22">Gooderham M</searchLink>; SKiN Centre for Dermatology, Peterborough, ON, Canada.; Department of Medicine, Queen's University, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stone+M%22">Stone M</searchLink>; Shenandoah Medical Center, Shenandoah, IA, USA.<br /><searchLink fieldCode="AU" term="%22Anadkat+MJ%22">Anadkat MJ</searchLink>; Department of Medicine, Division of Dermatology, Washington University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Katoulis+A%22">Katoulis A</searchLink>; 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Papakonstantis+M%22">Papakonstantis M</searchLink>; Department of Dermatology, 401 General Military Hospital of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Becherel+PA%22">Becherel PA</searchLink>; Department of Dermatology, Antony Private Hospital, Antony, France.<br /><searchLink fieldCode="AU" term="%22Szepietowski+JC%22">Szepietowski JC</searchLink>; Faculty of Medicine, Wrocław University of Science and Technology, Wrocław, Poland.; Department of Dermatovenereology, 4th Military Hospital, Wrocław, Poland.<br /><searchLink fieldCode="AU" term="%22van+der+Zee+HH%22">van der Zee HH</searchLink>; Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zouboulis+CC%22">Zouboulis CC</searchLink>; Departments of Dermatology, Venereology, Allergology and Immunology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.<br /><searchLink fieldCode="AU" term="%22Sayed+CJ%22">Sayed CJ</searchLink>; Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA.
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  Data: <searchLink fieldCode="JN" term="%220004041%22">The British journal of dermatology</searchLink> [Br J Dermatol] 2026 Jan 27; Vol. 194 (2), pp. 254-263.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0004041 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1365-2133 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070963%22">00070963 </searchLink><i>NLM ISO Abbreviation: </i>Br J Dermatol <i>Subsets: </i>MEDLINE
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