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MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.

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Title: MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.
Authors: Nguyen M; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Collier JJ; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Ignatenko O; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Morin G; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada., Goyon V; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Janer A; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Tiefensee Ribeiro C; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Milnerwood AJ; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada., Huang S; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montréal, Quebec, Canada., Desjardins M; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, Quebec, Canada., McBride HM; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. heidi.mcbride@mcgill.ca.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. heidi.mcbride@mcgill.ca.
Source: Nature cell biology [Nat Cell Biol] 2025 Oct; Vol. 27 (10), pp. 1708-1724. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+M%22">Nguyen M</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Collier+JJ%22">Collier JJ</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ignatenko+O%22">Ignatenko O</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Morin+G%22">Morin G</searchLink>; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Goyon+V%22">Goyon V</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Janer+A%22">Janer A</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tiefensee+Ribeiro+C%22">Tiefensee Ribeiro C</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Milnerwood+AJ%22">Milnerwood AJ</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Desjardins+M%22">Desjardins M</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22McBride+HM%22">McBride HM</searchLink>; Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada. heidi.mcbride@mcgill.ca.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. heidi.mcbride@mcgill.ca.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2025 Oct; Vol. 27 (10), pp. 1708-1724. <i>Date of Electronic Publication: </i>2025 Oct 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Macmillan+Magazines+Ltd%22">Macmillan Magazines Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100890575 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4679 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214657392%22">14657392 </searchLink><i>NLM ISO Abbreviation: </i>Nat Cell Biol <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct
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