Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.
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| Title: | Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. |
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| Authors: | Glossop PA; Sandexis Medicinal Chemistry Ltd, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9FF, U.K., Brear P; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Wright S; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Flanagan N; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Glossop MS; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Lane CAL; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Butt RP; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Hyvönen M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Cawkill D; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21587-21614. Date of Electronic Publication: 2025 Oct 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41085029 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Glossop+PA%22">Glossop PA</searchLink>; Sandexis Medicinal Chemistry Ltd, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9FF, U.K.<br /><searchLink fieldCode="AU" term="%22Brear+P%22">Brear P</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K.<br /><searchLink fieldCode="AU" term="%22Wright+S%22">Wright S</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K.<br /><searchLink fieldCode="AU" term="%22Flanagan+N%22">Flanagan N</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K.<br /><searchLink fieldCode="AU" term="%22Glossop+MS%22">Glossop MS</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K.<br /><searchLink fieldCode="AU" term="%22Lane+CAL%22">Lane CAL</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K.<br /><searchLink fieldCode="AU" term="%22Butt+RP%22">Butt RP</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K.<br /><searchLink fieldCode="AU" term="%22Spring+DR%22">Spring DR</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.<br /><searchLink fieldCode="AU" term="%22Hyvönen+M%22">Hyvönen M</searchLink>; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K.<br /><searchLink fieldCode="AU" term="%22Cawkill+D%22">Cawkill D</searchLink>; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21587-21614. <i>Date of Electronic Publication: </i>2025 Oct 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41085029 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.5c01807 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 21587 Titles: – TitleFull: Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Glossop PA – PersonEntity: Name: NameFull: Brear P – PersonEntity: Name: NameFull: Wright S – PersonEntity: Name: NameFull: Flanagan N – PersonEntity: Name: NameFull: Glossop MS – PersonEntity: Name: NameFull: Lane CAL – PersonEntity: Name: NameFull: Butt RP – PersonEntity: Name: NameFull: Spring DR – PersonEntity: Name: NameFull: Hyvönen M – PersonEntity: Name: NameFull: Cawkill D IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 10 Text: 2025 Oct 23 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 68 – Type: issue Value: 20 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
| ResultId | 1 |
