Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.
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| Title: | Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. |
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| Authors: | Glossop PA; Sandexis Medicinal Chemistry Ltd, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9FF, U.K., Brear P; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Wright S; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Flanagan N; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Glossop MS; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Lane CAL; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Butt RP; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Hyvönen M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Cawkill D; Apollo Therapeutics Ltd, 50-60 Station Road, Cambridge CB1 2JH, U.K. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21587-21614. Date of Electronic Publication: 2025 Oct 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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