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A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.

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Title: A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.
Authors: Raines B; Cellular and Molecular Biology Program and.; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Tseng-Rogenski S; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA., Dowdican AC; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Peris I; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Hinderman M; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Zawacki KP; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Barrie K; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Hodges Onishi G; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Dymond AM; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Luther TK; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Musser S; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA., Karaj Majchrowski B; Department of Pharmacology and.; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA., Brenner JC; Cellular and Molecular Biology Program and.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.; Department of Pharmacology and.; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA., Ahmed A; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Taylor DJ; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA., O'Connor CM; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA., Narla G; Cellular and Molecular Biology Program and.; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Oct 14; Vol. 135 (23). Date of Electronic Publication: 2025 Oct 14 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Raines+B%22">Raines B</searchLink>; Cellular and Molecular Biology Program and.; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Tseng-Rogenski+S%22">Tseng-Rogenski S</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Dowdican+AC%22">Dowdican AC</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Peris+I%22">Peris I</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Hinderman+M%22">Hinderman M</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Zawacki+KP%22">Zawacki KP</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Barrie+K%22">Barrie K</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Hodges+Onishi+G%22">Hodges Onishi G</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Dymond+AM%22">Dymond AM</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Luther+TK%22">Luther TK</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Musser+S%22">Musser S</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Karaj+Majchrowski+B%22">Karaj Majchrowski B</searchLink>; Department of Pharmacology and.; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+JC%22">Brenner JC</searchLink>; Cellular and Molecular Biology Program and.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.; Department of Pharmacology and.; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+A%22">Ahmed A</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+DJ%22">Taylor DJ</searchLink>; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22O'Connor+CM%22">O'Connor CM</searchLink>; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Narla+G%22">Narla G</searchLink>; Cellular and Molecular Biology Program and.; Department of Internal Medicine, Division of Genetic Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Oct 14; Vol. 135 (23). <i>Date of Electronic Publication: </i>2025 Oct 14 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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