Pharmacokinetic analysis of bumped-kinase inhibitors in horses demonstrates their potential utility for prevention and treatment of equine protozoal myeloencephalitis.

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Title: Pharmacokinetic analysis of bumped-kinase inhibitors in horses demonstrates their potential utility for prevention and treatment of equine protozoal myeloencephalitis.
Authors: Rocha IA; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., McPeek JL; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., Hulverson MA; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA., Choi R; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA., Orr K; Rood and Riddle Equine Hospital, Lexington, KY., Sponseller BT; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., Kennedy T; Eleven Bravo LLC, Westport, WI., Ojo KK; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA., Barrett LK; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA., Ruby R; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., Janes J; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., Reed SM; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.; Rood and Riddle Equine Hospital, Lexington, KY., Arnold SLM; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA., Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA., Page A; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY., Howe DK; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.
Source: American journal of veterinary research [Am J Vet Res] 2025 Oct 14; Vol. 87 (1). Date of Electronic Publication: 2025 Oct 14 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 0375011 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1943-5681 (Electronic) Linking ISSN: 00029645 NLM ISO Abbreviation: Am J Vet Res Subsets: MEDLINE
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  Data: Pharmacokinetic analysis of bumped-kinase inhibitors in horses demonstrates their potential utility for prevention and treatment of equine protozoal myeloencephalitis.
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  Data: <searchLink fieldCode="AU" term="%22Rocha+IA%22">Rocha IA</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22McPeek+JL%22">McPeek JL</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Hulverson+MA%22">Hulverson MA</searchLink>; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Choi+R%22">Choi R</searchLink>; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Orr+K%22">Orr K</searchLink>; Rood and Riddle Equine Hospital, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Sponseller+BT%22">Sponseller BT</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Kennedy+T%22">Kennedy T</searchLink>; Eleven Bravo LLC, Westport, WI.<br /><searchLink fieldCode="AU" term="%22Ojo+KK%22">Ojo KK</searchLink>; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Barrett+LK%22">Barrett LK</searchLink>; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Ruby+R%22">Ruby R</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Janes+J%22">Janes J</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Reed+SM%22">Reed SM</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.; Rood and Riddle Equine Hospital, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Arnold+SLM%22">Arnold SLM</searchLink>; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Van+Voorhis+WC%22">Van Voorhis WC</searchLink>; Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, Division of Allergy and Infectious Disease, School of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Page+A%22">Page A</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Howe+DK%22">Howe DK</searchLink>; Department of Veterinary Science, Martin-Gatton College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY.
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