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BioClock-optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms.

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Title: BioClock-optimizing Bright Light Therapy for adults with depression: a study protocol for a multicenter randomized clinical trial on treatment strategies, response predictors, and chronobiological and neurobiological mechanisms.
Authors: Visser E; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands. e.visser1@tue.nl., Rus-Oswald OG; Department of Clinical Psychology, Faculty of Social Sciences, Leiden University, Wassenaarseweg 2, 2333 AK, Leiden, The Netherlands., van der Does AJW; Leids Universitair Behandel- en Expertise Centrum, Sandifortdreef 17, Leiden, 2333 ZZ, The Netherlands., Gordijn MCM; Chrono@Work B.V., Friesestraatweg 213, Groningen, 9743 AD, The Netherlands.; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, Groningen, 9747 AG, The Netherlands., Marcelis MC; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands.; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Minderbroedersberg 4-6 , Maastricht, 6211 LK, The Netherlands., de Kort YAW; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands., Oomen PP; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands., Schlangen LJM; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands., Seetsen T; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands., Simons CJP; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands.; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Minderbroedersberg 4-6 , Maastricht, 6211 LK, The Netherlands., Antypa N; Department of Clinical Psychology, Faculty of Social Sciences, Leiden University, Wassenaarseweg 2, 2333 AK, Leiden, The Netherlands.
Source: Trials [Trials] 2025 Oct 14; Vol. 26 (1), pp. 411. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Visser+E%22">Visser E</searchLink>; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands. e.visser1@tue.nl.<br /><searchLink fieldCode="AU" term="%22Rus-Oswald+OG%22">Rus-Oswald OG</searchLink>; Department of Clinical Psychology, Faculty of Social Sciences, Leiden University, Wassenaarseweg 2, 2333 AK, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Does+AJW%22">van der Does AJW</searchLink>; Leids Universitair Behandel- en Expertise Centrum, Sandifortdreef 17, Leiden, 2333 ZZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gordijn+MCM%22">Gordijn MCM</searchLink>; Chrono@Work B.V., Friesestraatweg 213, Groningen, 9743 AD, The Netherlands.; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, Groningen, 9747 AG, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Marcelis+MC%22">Marcelis MC</searchLink>; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands.; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Minderbroedersberg 4-6 , Maastricht, 6211 LK, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Kort+YAW%22">de Kort YAW</searchLink>; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Oomen+PP%22">Oomen PP</searchLink>; Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schlangen+LJM%22">Schlangen LJM</searchLink>; Human Technology Interaction group, Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Seetsen+T%22">Seetsen T</searchLink>; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Simons+CJP%22">Simons CJP</searchLink>; GGzE Mental Health Institute of Eindhoven and the Kempen, Eindhoven, 5626 ND, Dokter Poletlaan 40, The Netherlands.; Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Minderbroedersberg 4-6 , Maastricht, 6211 LK, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Antypa+N%22">Antypa N</searchLink>; Department of Clinical Psychology, Faculty of Social Sciences, Leiden University, Wassenaarseweg 2, 2333 AK, Leiden, The Netherlands.
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              Text: 2025 Oct 14
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