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Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer.

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Title: Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer.
Authors: Jeon JH; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, MI, 48109, Ann Arbor, United States.; Biointerfaces Institute, University of Michigan, MI, 48109, Ann Arbor, United States., Slayton MD; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Krinkel B; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Animasahun O; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Shankaran A; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Wuchu F; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Nenwani M; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Farah Z; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Burke J; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Achreja A; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Nilaj B; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Kohagen K; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Eu YH; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Rosenfeld A; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Collard M; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Bao L; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Cheng X; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Kleer C; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States., Squire C; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Loomes K; School of Biological Sciences, University of Auckland, Auckland, New Zealand., Nagrath D; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. dnagrath@umich.edu.; Department of Chemical Engineering, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Laboratory for Systems Biology of Human Diseases, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Biointerfaces Institute, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu., Merajver SD; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. smerajve@med.umich.edu.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States. smerajve@med.umich.edu.
Source: Cancer & metabolism [Cancer Metab] 2025 Oct 14; Vol. 13 (1), pp. 42. Date of Electronic Publication: 2025 Oct 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Jeon+JH%22">Jeon JH</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, MI, 48109, Ann Arbor, United States.; Biointerfaces Institute, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Slayton+MD%22">Slayton MD</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Krinkel+B%22">Krinkel B</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Animasahun+O%22">Animasahun O</searchLink>; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Shankaran+A%22">Shankaran A</searchLink>; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Wuchu+F%22">Wuchu F</searchLink>; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Nenwani+M%22">Nenwani M</searchLink>; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Farah+Z%22">Farah Z</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Burke+J%22">Burke J</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Achreja+A%22">Achreja A</searchLink>; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Nilaj+B%22">Nilaj B</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Kohagen+K%22">Kohagen K</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Eu+YH%22">Eu YH</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Rosenfeld+A%22">Rosenfeld A</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Collard+M%22">Collard M</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Bao+L%22">Bao L</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Kleer+C%22">Kleer C</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States.<br /><searchLink fieldCode="AU" term="%22Squire+C%22">Squire C</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Loomes+K%22">Loomes K</searchLink>; School of Biological Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Nagrath+D%22">Nagrath D</searchLink>; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Department of Biomedical Engineering, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. dnagrath@umich.edu.; Department of Chemical Engineering, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Laboratory for Systems Biology of Human Diseases, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.; Biointerfaces Institute, University of Michigan, MI, 48109, Ann Arbor, United States. dnagrath@umich.edu.<br /><searchLink fieldCode="AU" term="%22Merajver+SD%22">Merajver SD</searchLink>; Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. smerajve@med.umich.edu.; Rogel Cancer Center, Michigan Medicine, University of Michigan, MI, 48109, Ann Arbor, United States. smerajve@med.umich.edu.
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