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Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.

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Bibliographic Details
Title: Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.
Authors: Nuñez R; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Bursch KL; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Makowski SJ; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Xue M; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Cozzolino KA; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Shishodia S; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Keyes RF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Zhu N; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Smith BC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 Sep 16; Vol. 16 (10), pp. 1955-1962. Date of Electronic Publication: 2025 Sep 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.5c00352