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Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.

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Title: Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.
Authors: Nuñez R; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Bursch KL; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Makowski SJ; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Xue M; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Cozzolino KA; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Shishodia S; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Keyes RF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Zhu N; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States., Smith BC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 Sep 16; Vol. 16 (10), pp. 1955-1962. Date of Electronic Publication: 2025 Sep 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.
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  Data: <searchLink fieldCode="AU" term="%22Nuñez+R%22">Nuñez R</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Bursch+KL%22">Bursch KL</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Makowski+SJ%22">Makowski SJ</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Xue+M%22">Xue M</searchLink>; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Cozzolino+KA%22">Cozzolino KA</searchLink>; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Shishodia+S%22">Shishodia S</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Keyes+RF%22">Keyes RF</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+N%22">Zhu N</searchLink>; Synthetic Biology Program, J Craig Venter Institute, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Smith+BC%22">Smith BC</searchLink>; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2025 Sep 16; Vol. 16 (10), pp. 1955-1962. <i>Date of Electronic Publication: </i>2025 Sep 16 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1021/acsmedchemlett.5c00352
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        Text: English
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        StartPage: 1955
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      – TitleFull: Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket.
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              Text: 2025 Sep 16
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