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Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.

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Title: Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Authors: Ruan LJ; Department of Pneumology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China., Weng KQ; Department of Urology, The Affiliated Hospital of Putian University, Putian, China., Zhang WY; Center for Vascular Surgery and Interventional Oncology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zhuang YN; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China., Li J; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China., Lin LM; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China., Chen YT; Department of Oncology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China., Zeng YM; Department of Pneumology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.; Fujian Key Laboratory of Lung Stem Cells, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Source: Frontiers in immunology [Front Immunol] 2025 Sep 29; Vol. 16, pp. 1651270. Date of Electronic Publication: 2025 Sep 29 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ruan+LJ%22">Ruan LJ</searchLink>; Department of Pneumology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Weng+KQ%22">Weng KQ</searchLink>; Department of Urology, The Affiliated Hospital of Putian University, Putian, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WY%22">Zhang WY</searchLink>; Center for Vascular Surgery and Interventional Oncology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+YN%22">Zhuang YN</searchLink>; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Lin+LM%22">Lin LM</searchLink>; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Putian University, Putian, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+YT%22">Chen YT</searchLink>; Department of Oncology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zeng+YM%22">Zeng YM</searchLink>; Department of Pneumology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.; Fujian Key Laboratory of Lung Stem Cells, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
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        Value: 10.3389/fimmu.2025.1651270
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              Text: 2025 Sep 29
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