An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques.
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| Title: | An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques. |
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| Authors: | Lasrado N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Wang L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Rössler A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Chaudhari J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Wang Q; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Stone JJ; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Granados-Contreras FA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Wu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Cabrera-Barragan DN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Waller-Pulido A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Nangle SJ; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Shah K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Boduch R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Warke S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Cook A; Bioqual Inc., Rockville, MD 20850, USA., Kitajewski C; Bioqual Inc., Rockville, MD 20850, USA., Pessaint L; Bioqual Inc., Rockville, MD 20850, USA., Lewis MG; Bioqual Inc., Rockville, MD 20850, USA., Andersen H; Bioqual Inc., Rockville, MD 20850, USA., Martinot AJ; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., McNamara RP; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Oct 15; Vol. 17 (820), pp. eady2282. Date of Electronic Publication: 2025 Oct 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.ady2282 |
