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An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques.

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Title: An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques.
Authors: Lasrado N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Wang L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Rössler A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Chaudhari J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Wang Q; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Stone JJ; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Granados-Contreras FA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Wu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Cabrera-Barragan DN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Waller-Pulido A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Nangle SJ; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Shah K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Boduch R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Warke S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Cook A; Bioqual Inc., Rockville, MD 20850, USA., Kitajewski C; Bioqual Inc., Rockville, MD 20850, USA., Pessaint L; Bioqual Inc., Rockville, MD 20850, USA., Lewis MG; Bioqual Inc., Rockville, MD 20850, USA., Andersen H; Bioqual Inc., Rockville, MD 20850, USA., Martinot AJ; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., McNamara RP; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Oct 15; Vol. 17 (820), pp. eady2282. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques.
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  Data: <searchLink fieldCode="AU" term="%22Lasrado+N%22">Lasrado N</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Rössler+A%22">Rössler A</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhari+J%22">Chaudhari J</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Stone+JJ%22">Stone JJ</searchLink>; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.<br /><searchLink fieldCode="AU" term="%22Granados-Contreras+FA%22">Granados-Contreras FA</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Cabrera-Barragan+DN%22">Cabrera-Barragan DN</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Waller-Pulido+A%22">Waller-Pulido A</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Nangle+SJ%22">Nangle SJ</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Shah+K%22">Shah K</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Boduch+R%22">Boduch R</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Warke+S%22">Warke S</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Cook+A%22">Cook A</searchLink>; Bioqual Inc., Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Kitajewski+C%22">Kitajewski C</searchLink>; Bioqual Inc., Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Pessaint+L%22">Pessaint L</searchLink>; Bioqual Inc., Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+MG%22">Lewis MG</searchLink>; Bioqual Inc., Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Andersen+H%22">Andersen H</searchLink>; Bioqual Inc., Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Martinot+AJ%22">Martinot AJ</searchLink>; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.<br /><searchLink fieldCode="AU" term="%22McNamara+RP%22">McNamara RP</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Barouch+DH%22">Barouch DH</searchLink>; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge MA 02139, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Oct 15; Vol. 17 (820), pp. eady2282. <i>Date of Electronic Publication: </i>2025 Oct 15.
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