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Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice.

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Title: Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice.
Authors: Hendricks GG; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Grigoryan L; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Navarro MJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Catanzaro NJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hubbard ML; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Powers JM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Mattocks M; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Treichel C; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA., Lee J; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Ellis D; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Wang JYJ; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Cheng S; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Miranda MC; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Valdez A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Chao CW; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA., Chan S; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Men C; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Johnson MR; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Zepeda SK; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Ols S; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Hui H; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Wu SY; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Lujan V; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Sung MMH; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada., Leaf EM; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., King NP; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Oct 15; Vol. 17 (820), pp. eadu2085. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adu2085