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A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity.

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Title: A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity.
Authors: Ashlaw EF; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA., Elfers CT; Seattle Children's Research Institute, Seattle, WA, 98195, USA; University of Washington School of Medicine, Department of Pediatrics, Seattle, WA, 98195, USA., Chichura KS; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA., Miranda IC; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA., McGivney A; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA., Chepurny OG; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA., Holz GG; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA; State University of New York, Upstate Medical University, Department of Pharmacology, Syracuse, NY, 13245, USA., Mullins G; Seattle Children's Research Institute, Seattle, WA, 98195, USA., den Hartigh LJ; University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute, Seattle, WA, 98195, USA., Liu Y; University of Washington, Department of Laboratory Medicine and Pathology, Seattle, WA, 98195, USA., Roth CL; Seattle Children's Research Institute, Seattle, WA, 98195, USA; University of Washington School of Medicine, Department of Pediatrics, Seattle, WA, 98195, USA. Electronic address: Christian.roth@seattlechildrens.org., Doyle RP; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA; State University of New York, Upstate Medical University, Department of Pharmacology, Syracuse, NY, 13245, USA. Electronic address: rpdoyle@syr.edu.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jan; Vol. 174, pp. 156414. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity.
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  Data: <searchLink fieldCode="AU" term="%22Ashlaw+EF%22">Ashlaw EF</searchLink>; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA.<br /><searchLink fieldCode="AU" term="%22Elfers+CT%22">Elfers CT</searchLink>; Seattle Children's Research Institute, Seattle, WA, 98195, USA; University of Washington School of Medicine, Department of Pediatrics, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Chichura+KS%22">Chichura KS</searchLink>; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA.<br /><searchLink fieldCode="AU" term="%22Miranda+IC%22">Miranda IC</searchLink>; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA.<br /><searchLink fieldCode="AU" term="%22McGivney+A%22">McGivney A</searchLink>; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA.<br /><searchLink fieldCode="AU" term="%22Chepurny+OG%22">Chepurny OG</searchLink>; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA.<br /><searchLink fieldCode="AU" term="%22Holz+GG%22">Holz GG</searchLink>; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA; State University of New York, Upstate Medical University, Department of Pharmacology, Syracuse, NY, 13245, USA.<br /><searchLink fieldCode="AU" term="%22Mullins+G%22">Mullins G</searchLink>; Seattle Children's Research Institute, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22den+Hartigh+LJ%22">den Hartigh LJ</searchLink>; University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; University of Washington, Department of Laboratory Medicine and Pathology, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Roth+CL%22">Roth CL</searchLink>; Seattle Children's Research Institute, Seattle, WA, 98195, USA; University of Washington School of Medicine, Department of Pediatrics, Seattle, WA, 98195, USA. Electronic address: Christian.roth@seattlechildrens.org.<br /><searchLink fieldCode="AU" term="%22Doyle+RP%22">Doyle RP</searchLink>; Syracuse University, Department of Chemistry, 111 College Place, Syracuse, NY, 13244, USA; State University of New York, Upstate Medical University, Department of Medicine, Syracuse, NY, 13245, USA; State University of New York, Upstate Medical University, Department of Pharmacology, Syracuse, NY, 13245, USA. Electronic address: rpdoyle@syr.edu.
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        Value: 10.1016/j.metabol.2025.156414
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              Text: 2026 Jan
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