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The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells.

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Title: The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells.
Authors: Panetti C; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Daetwyler R; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Moncsek A; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Patikas N; The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA., Agrafiotis A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Tang A; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; La Trobe University, Bundoora, Victoria, Australia., Andreata F; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Fumagalli V; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., De Lima J; Department of Biomedicine, University of Basel, Basel, Switzerland., Wen L; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia., King CG; Department of Biomedicine, University of Basel, Basel, Switzerland., Vasanthakumar A; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; La Trobe University, Bundoora, Victoria, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Iannacone M; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Kallies A; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; Institute of Molecular Medicine & Experimental Immunology, University Hospital Bonn, Bonn, Germany., Yermanos A; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; Botnar Institute of Immune Engineering, Basel, Switzerland., Hemberg M; The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA., Joller N; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. nicole.joller@uzh.ch.; Center for Human Immunology, University of Zurich, Zurich, Switzerland. nicole.joller@uzh.ch.
Source: Nature immunology [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 2074-2085. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Panetti+C%22">Panetti C</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Daetwyler+R%22">Daetwyler R</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moncsek+A%22">Moncsek A</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Patikas+N%22">Patikas N</searchLink>; The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Agrafiotis+A%22">Agrafiotis A</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Institute of Microbiology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tang+A%22">Tang A</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; La Trobe University, Bundoora, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Andreata+F%22">Andreata F</searchLink>; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fumagalli+V%22">Fumagalli V</searchLink>; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Lima+J%22">De Lima J</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wen+L%22">Wen L</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22King+CG%22">King CG</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vasanthakumar+A%22">Vasanthakumar A</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; La Trobe University, Bundoora, Victoria, Australia.; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Iannacone+M%22">Iannacone M</searchLink>; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Kallies+A%22">Kallies A</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia.; Institute of Molecular Medicine & Experimental Immunology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Yermanos+A%22">Yermanos A</searchLink>; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.; Botnar Institute of Immune Engineering, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hemberg+M%22">Hemberg M</searchLink>; The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Joller+N%22">Joller N</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. nicole.joller@uzh.ch.; Center for Human Immunology, University of Zurich, Zurich, Switzerland. nicole.joller@uzh.ch.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2025 Nov; Vol. 26 (11), pp. 2074-2085. <i>Date of Electronic Publication: </i>2025 Oct 15.
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