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PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models.

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Title: PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models.
Authors: Albornoz EA; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia., Mardon K; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia., Bhalla R; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia., Kumar V; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia., Stimson DHR; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia., Cowin G; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia., Cui CS; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia., Butler MS; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia., Pelingon R; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia., Gordon R; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.; Translational Research Institute (TRI), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane 4102, Australia., Coll RC; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia.; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK., Schroder K; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia., Halai R; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK., MacLeod AM; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK., Matthews K; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK., Robertson AAB; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia., Cooper MA; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK., Woodruff TM; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Source: Brain : a journal of neurology [Brain] 2026 Apr 07; Vol. 149 (4), pp. 1289-1301.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models.
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  Data: <searchLink fieldCode="AU" term="%22Albornoz+EA%22">Albornoz EA</searchLink>; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Mardon+K%22">Mardon K</searchLink>; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Bhalla+R%22">Bhalla R</searchLink>; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Kumar+V%22">Kumar V</searchLink>; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Stimson+DHR%22">Stimson DHR</searchLink>; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Cowin+G%22">Cowin G</searchLink>; Centre for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Cui+CS%22">Cui CS</searchLink>; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Butler+MS%22">Butler MS</searchLink>; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Pelingon+R%22">Pelingon R</searchLink>; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Gordon+R%22">Gordon R</searchLink>; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.; Translational Research Institute (TRI), School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane 4102, Australia.<br /><searchLink fieldCode="AU" term="%22Coll+RC%22">Coll RC</searchLink>; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia.; The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22Schroder+K%22">Schroder K</searchLink>; The Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Halai+R%22">Halai R</searchLink>; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK.<br /><searchLink fieldCode="AU" term="%22MacLeod+AM%22">MacLeod AM</searchLink>; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+K%22">Matthews K</searchLink>; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK.<br /><searchLink fieldCode="AU" term="%22Robertson+AAB%22">Robertson AAB</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Cooper+MA%22">Cooper MA</searchLink>; Inflazome Ltd, Welwyn Garden City AL7 1TW, UK.; Sitala Bio Ltd., Shelford, Cambridgeshire CB22 1LD, UK.<br /><searchLink fieldCode="AU" term="%22Woodruff+TM%22">Woodruff TM</searchLink>; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
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