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An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process.

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Title: An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process.
Authors: Leist M; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, Konstanz, Germany., Tangianu S; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, Konstanz, Germany., Affourtit F; Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Braakhuis H; Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, The Netherlands., Colbourne J; Centre for Environmental Research and Justice, and School of Biosciences, University of Birmingham, Birmingham, United Kingdom., Cöllen E; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Dreser N; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Escher SE; Fraunhofer ITEM, Safety Assessment and Toxicology, Hannover, Germany., Gardner I; Certara Predictive Technologies, Sheffield, United Kingdom., Hahn S; Fraunhofer ITEM, Safety Assessment and Toxicology, Hannover, Germany., Hardy B; Edelweiss Connect GmbH, Basel, Switzerland., Herzler M; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Islam B; Certara Predictive Technologies, Sheffield, United Kingdom., Kamp H; BASF Metabolome Solutions GmbH, Berlin, Germany., Magel V; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany., Marx-Stoelting P; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Moné MJ; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Lundquist P; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Ottenbros I; Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, The Netherlands., Ouedraogo G; L'Oréal Research & Innovation, Aulnay-sous-Bois, France., Pallocca G; Humane World for Animals Europe, Brussels, Belgium., van de Water B; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Vinken M; Vrije Universiteit Brussel, Brussels, Belgium., White A; Unilever PLC, Sharnbrook, United Kingdom., Pastor M; Research Programme on Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute, Barcelona, Spain., Luijten M; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Source: ALTEX [ALTEX] 2026; Vol. 43 (1), pp. 158-175. Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article
Journal Info: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Leist+M%22">Leist M</searchLink>; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Tangianu+S%22">Tangianu S</searchLink>; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.; CAAT-Europe, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Affourtit+F%22">Affourtit F</searchLink>; Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Braakhuis+H%22">Braakhuis H</searchLink>; Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Colbourne+J%22">Colbourne J</searchLink>; Centre for Environmental Research and Justice, and School of Biosciences, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cöllen+E%22">Cöllen E</searchLink>; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Dreser+N%22">Dreser N</searchLink>; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Escher+SE%22">Escher SE</searchLink>; Fraunhofer ITEM, Safety Assessment and Toxicology, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Gardner+I%22">Gardner I</searchLink>; Certara Predictive Technologies, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hahn+S%22">Hahn S</searchLink>; Fraunhofer ITEM, Safety Assessment and Toxicology, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hardy+B%22">Hardy B</searchLink>; Edelweiss Connect GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Herzler+M%22">Herzler M</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Islam+B%22">Islam B</searchLink>; Certara Predictive Technologies, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kamp+H%22">Kamp H</searchLink>; BASF Metabolome Solutions GmbH, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Magel+V%22">Magel V</searchLink>; In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.<br /><searchLink fieldCode="AU" term="%22Marx-Stoelting+P%22">Marx-Stoelting P</searchLink>; German Federal Institute for Risk Assessment (BfR), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Moné+MJ%22">Moné MJ</searchLink>; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lundquist+P%22">Lundquist P</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ottenbros+I%22">Ottenbros I</searchLink>; Department of Risk Analysis for Prevention, Innovation and Development, Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ouedraogo+G%22">Ouedraogo G</searchLink>; L'Oréal Research & Innovation, Aulnay-sous-Bois, France.<br /><searchLink fieldCode="AU" term="%22Pallocca+G%22">Pallocca G</searchLink>; Humane World for Animals Europe, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22van+de+Water+B%22">van de Water B</searchLink>; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vinken+M%22">Vinken M</searchLink>; Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22White+A%22">White A</searchLink>; Unilever PLC, Sharnbrook, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pastor+M%22">Pastor M</searchLink>; Research Programme on Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Luijten+M%22">Luijten M</searchLink>; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
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