Innovative therapeutic cancer vaccine PDC∗lung01 with or without anti-PD-1: an open-label, dose-escalation phase I/II study in non-small-cell lung cancer.

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Title: Innovative therapeutic cancer vaccine PDClung01 with or without anti-PD-1: an open-label, dose-escalation phase I/II study in non-small-cell lung cancer.
Authors: Vansteenkiste J; Respiratory Oncology Unit (Pulmonology), University Hospitals Leuven, Leuven, Belgium. Electronic address: johan.vansteenkiste@uzleuven.be., Demedts I; Pulmonary Diseases, AZ Delta Campus Rumbeke, Roeselare, Belgium., Cuppens K; Pulmonology & Thoracic Oncology Department, Jessa Hospital, Hasselt, Belgium., Pons-Tostivint E; Medical Oncology Department, Nantes University Hospital, Nantes, France., Wauters E; Respiratory Oncology Unit (Pulmonology), University Hospitals Leuven, Leuven, Belgium., Borm FJ; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands., Sibille A; Department of Pulmonology, Centre Hospitalier Universitaire de Liège, Liège, Belgium., Colinet B; Pneumology Department, GHdC, Grand Hôpital de Charleroi, Site Notre Dame, Charleroi, Belgium., Pérol M; Medical Oncology Department, Centre Léon Bérard, Lyon, France., Theelen WSME; Thoracic Oncology Department, Netherlands Cancer Institute, Amsterdam, The Netherlands., Biesma B; Pulmonology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands., Van De Kerkhove C; Clinical Study Centre, Vitaz campus Sint-Niklaas Moerland, Sint-Niklaas, Belgium., Buchmeier E; Hematology & Oncology Department, Kliniken der Stadt Koln gGmbH, Köln, Germany., Althoff FC; Hemato-Oncology Department, Universitätsklinikum Frankfurt (Johannes-Wolfgang Goethe-Universität), Frankfurt Am Main, Germany., Derijcke S; Pulmonology - Thoracic Oncology, AZ Groeninge, Campus Kennedylaan, Kortrijk, Belgium., Moro-Sibilot D; Thoracic Oncology, SHUPP, CHU Grenoble-Alpes, Grenoble, France., Laulagnier K; PDC(∗)line Pharma France, Grenoble, France., Halioua E; PDC(∗)line Pharma Belgique, Liège, Belgium., Levy L; PDC(∗)line Pharma France, Grenoble, France., Genin M; RLM Consulting, Louvain-la-Neuve, Belgium., Michel S; PDC(∗)line Pharma Belgique, Liège, Belgium., Dedry C; PDC(∗)line Pharma Belgique, Liège, Belgium., Duchayne C; PDC(∗)line Pharma Belgique, Liège, Belgium., Collodoro M; PDC(∗)line Pharma Belgique, Liège, Belgium., Renard F; PDC(∗)line Pharma Belgique, Liège, Belgium., Adriaenssens S; PDC(∗)line Pharma Belgique, Liège, Belgium., De Vos B; PDC(∗)line Pharma Belgique, Liège, Belgium., Cantero F; PDC(∗)line Pharma Belgique, Liège, Belgium., Plumas J; PDC(∗)line Pharma Belgique, Liège, Belgium., Skrzypski M; Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland.
Source: ESMO open [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105844. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
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  Data: Innovative therapeutic cancer vaccine PDC<superscript>∗</superscript>lung01 with or without anti-PD-1: an open-label, dose-escalation phase I/II study in non-small-cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Vansteenkiste+J%22">Vansteenkiste J</searchLink>; Respiratory Oncology Unit (Pulmonology), University Hospitals Leuven, Leuven, Belgium. Electronic address: johan.vansteenkiste@uzleuven.be.<br /><searchLink fieldCode="AU" term="%22Demedts+I%22">Demedts I</searchLink>; Pulmonary Diseases, AZ Delta Campus Rumbeke, Roeselare, Belgium.<br /><searchLink fieldCode="AU" term="%22Cuppens+K%22">Cuppens K</searchLink>; Pulmonology & Thoracic Oncology Department, Jessa Hospital, Hasselt, Belgium.<br /><searchLink fieldCode="AU" term="%22Pons-Tostivint+E%22">Pons-Tostivint E</searchLink>; Medical Oncology Department, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Wauters+E%22">Wauters E</searchLink>; Respiratory Oncology Unit (Pulmonology), University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Borm+FJ%22">Borm FJ</searchLink>; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sibille+A%22">Sibille A</searchLink>; Department of Pulmonology, Centre Hospitalier Universitaire de Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Colinet+B%22">Colinet B</searchLink>; Pneumology Department, GHdC, Grand Hôpital de Charleroi, Site Notre Dame, Charleroi, Belgium.<br /><searchLink fieldCode="AU" term="%22Pérol+M%22">Pérol M</searchLink>; Medical Oncology Department, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Theelen+WSME%22">Theelen WSME</searchLink>; Thoracic Oncology Department, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Biesma+B%22">Biesma B</searchLink>; Pulmonology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+De+Kerkhove+C%22">Van De Kerkhove C</searchLink>; Clinical Study Centre, Vitaz campus Sint-Niklaas Moerland, Sint-Niklaas, Belgium.<br /><searchLink fieldCode="AU" term="%22Buchmeier+E%22">Buchmeier E</searchLink>; Hematology & Oncology Department, Kliniken der Stadt Koln gGmbH, Köln, Germany.<br /><searchLink fieldCode="AU" term="%22Althoff+FC%22">Althoff FC</searchLink>; Hemato-Oncology Department, Universitätsklinikum Frankfurt (Johannes-Wolfgang Goethe-Universität), Frankfurt Am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Derijcke+S%22">Derijcke S</searchLink>; Pulmonology - Thoracic Oncology, AZ Groeninge, Campus Kennedylaan, Kortrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Moro-Sibilot+D%22">Moro-Sibilot D</searchLink>; Thoracic Oncology, SHUPP, CHU Grenoble-Alpes, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Laulagnier+K%22">Laulagnier K</searchLink>; PDC(∗)line Pharma France, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Halioua+E%22">Halioua E</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Levy+L%22">Levy L</searchLink>; PDC(∗)line Pharma France, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Genin+M%22">Genin M</searchLink>; RLM Consulting, Louvain-la-Neuve, Belgium.<br /><searchLink fieldCode="AU" term="%22Michel+S%22">Michel S</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Dedry+C%22">Dedry C</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Duchayne+C%22">Duchayne C</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Collodoro+M%22">Collodoro M</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Renard+F%22">Renard F</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Adriaenssens+S%22">Adriaenssens S</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Vos+B%22">De Vos B</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Cantero+F%22">Cantero F</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Plumas+J%22">Plumas J</searchLink>; PDC(∗)line Pharma Belgique, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22Skrzypski+M%22">Skrzypski M</searchLink>; Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105844. <i>Date of Electronic Publication: </i>2025 Oct 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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