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Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism.

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Title: Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism.
Authors: Byrne NJ; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Koentges C; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Pfeil K; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Lueg JC; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Bakshi S; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Tarkhnishvili A; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Vosko I; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Gollmer J; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Birkle LC; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Rathner T; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Birkle S; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Tang S; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Rau C; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Hoffmann MM; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Clinical Chemistry and Laboratory Medicine, Medical Center-University of Freiburg, Freiburg, Germany., Odening KE; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.; Translational Cardiology, Department of Cardiology, Bern University Hospital, Bern, Switzerland., Barnes S; Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Wilson LS; Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Ljubojevic-Holzer S; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria., Wallner M; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., von Lewinski D; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Rainer P; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Sedej S; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia., Sourij H; Division of Endocrinology and Dialectology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Bode C; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany., Wende AR; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Zirlik A; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria., Bugger H; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Source: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2025 Nov; Vol. 241 (11), pp. e70120.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print Cited Medium: Internet ISSN: 1748-1716 (Electronic) Linking ISSN: 17481708 NLM ISO Abbreviation: Acta Physiol (Oxf) Subsets: MEDLINE
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  Data: Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Byrne+NJ%22">Byrne NJ</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Koentges+C%22">Koentges C</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfeil+K%22">Pfeil K</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Lueg+JC%22">Lueg JC</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bakshi+S%22">Bakshi S</searchLink>; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Tarkhnishvili+A%22">Tarkhnishvili A</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vosko+I%22">Vosko I</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Gollmer+J%22">Gollmer J</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Birkle+LC%22">Birkle LC</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rathner+T%22">Rathner T</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Birkle+S%22">Birkle S</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tang+S%22">Tang S</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rau+C%22">Rau C</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+MM%22">Hoffmann MM</searchLink>; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Clinical Chemistry and Laboratory Medicine, Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Odening+KE%22">Odening KE</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.; Translational Cardiology, Department of Cardiology, Bern University Hospital, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Barnes+S%22">Barnes S</searchLink>; Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+LS%22">Wilson LS</searchLink>; Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Ljubojevic-Holzer+S%22">Ljubojevic-Holzer S</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Wallner+M%22">Wallner M</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22von+Lewinski+D%22">von Lewinski D</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Rainer+P%22">Rainer P</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Sedej+S%22">Sedej S</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.<br /><searchLink fieldCode="AU" term="%22Sourij+H%22">Sourij H</searchLink>; Division of Endocrinology and Dialectology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Bode+C%22">Bode C</searchLink>; Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wende+AR%22">Wende AR</searchLink>; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Zirlik+A%22">Zirlik A</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Bugger+H%22">Bugger H</searchLink>; Department of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.
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