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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma.

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Title: Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma.
Authors: Safari M; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Scotto L; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Basseville A; Omics Data Science Unit, Institut de Cancérologie de l'Ouest; F-, Angers 49055, France., Litman T; University of Copenhagen, Copenhagen, Denmark., Xue H; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA., Petrukhin L; James J Peters VA Medical Center; New York, NY, USA., Zhou P; James J Peters VA Medical Center; New York, NY, USA., Remotti HE; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA., Ku A; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA., Morales DV; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Damoci C; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Zhu M; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA., Maddipati R; Department of Internal Medicine and Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA., Hull KG; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA., Robey RW; Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Olive KP; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Fojo T; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; James J Peters VA Medical Center; New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA., Romo D; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA., Bates SE; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; James J Peters VA Medical Center; New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: seb2227@cumc.columbia.edu.
Source: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2026 Jan; Vol. 84, pp. 101312. Date of Electronic Publication: 2025 Oct 04.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9815369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2084 (Electronic) Linking ISSN: 13687646 NLM ISO Abbreviation: Drug Resist Updat Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Safari+M%22">Safari M</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Scotto+L%22">Scotto L</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Basseville+A%22">Basseville A</searchLink>; Omics Data Science Unit, Institut de Cancérologie de l'Ouest; F-, Angers 49055, France.<br /><searchLink fieldCode="AU" term="%22Litman+T%22">Litman T</searchLink>; University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Xue+H%22">Xue H</searchLink>; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA.<br /><searchLink fieldCode="AU" term="%22Petrukhin+L%22">Petrukhin L</searchLink>; James J Peters VA Medical Center; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; James J Peters VA Medical Center; New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Remotti+HE%22">Remotti HE</searchLink>; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ku+A%22">Ku A</searchLink>; Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Morales+DV%22">Morales DV</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Damoci+C%22">Damoci C</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA.<br /><searchLink fieldCode="AU" term="%22Maddipati+R%22">Maddipati R</searchLink>; Department of Internal Medicine and Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hull+KG%22">Hull KG</searchLink>; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA.<br /><searchLink fieldCode="AU" term="%22Robey+RW%22">Robey RW</searchLink>; Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Olive+KP%22">Olive KP</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fojo+T%22">Fojo T</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; James J Peters VA Medical Center; New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Romo+D%22">Romo D</searchLink>; Department of Chemistry and Biochemistry & The Baylor Synthesis and Drug-Lead Discovery Lab, Baylor University, Waco, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bates+SE%22">Bates SE</searchLink>; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; James J Peters VA Medical Center; New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: seb2227@cumc.columbia.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>9815369 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-2084 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213687646%22">13687646 </searchLink><i>NLM ISO Abbreviation: </i>Drug Resist Updat <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.drup.2025.101312
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        Text: English
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              Text: 2026 Jan
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