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Mental health trajectories of adolescents treated with psychotropic medications: insights from the european milestone study.

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Title: Mental health trajectories of adolescents treated with psychotropic medications: insights from the european milestone study.
Authors: Magno M; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Martella D; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Leone S; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Allibrio G; Child and Adolescent Neuropsychiatry, ASST Bergamo Ovest, Treviglio, Italy., Bertani A; Unit of Youth Psychopathology, ASST Santi Paolo e Carlo, Milan, Italy., Caselani E; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Conti P; Child and Adolescent Neuropsychiatry, ASST Lariana, Como, Italy., Cortese S; Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences [CNS and Psychiatry], Faculty of Medicine, University of Southampton, Southampton, UK.; Solent NHS Trust, Southampton, UK.; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, New York, USA.; DiMePRe-J-Department of Precision and Rigenerative Medicine-Jonic Area, University of Bari 'Aldo Moro', Bari, Italy., Dieleman G; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands., Franic T; University Hospital of Split, Department of Psychiatry, Medical School University of Split, Split, Croatia., Gerritsen S; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands., Maffezzoni D; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Margari F; Dept of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Bari, Italy., Martinelli O; Child and Adolescent Neuropsychiatry, ASST Lecco, Lecco, Italy., McNicholas F; Lucena Clinic, Child and Adolescent Mental Health Services, Saint John of God, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.; Children's Health Ireland at Crumlin, Dublin, Ireland., Micciolo R; Centre for Medical Sciences, Department of Psychology and Cognitive Sciences, University of Trento, Trento, Italy., Nacinovich R; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.; Child and Adolescent Neuropsychiatry, IRCCS San Gerardo dei Tintori, Monza, Italy., Purper Ouakil D; University Hospital of Montpellier, MPEA1, Montpellier, France.; INSERM U 1018 CESP, Villejuif, France., Pastore A; Policlinico Hospital, Unit of Adolescent Psychiatric Emergency, Bari, Italy., Rinaldi F; Child and Adolescent Neuropsychiatry, ASST Valcamonica, Breno, Italy., Santosh P; Institute of Psychiatry, Psychology and Neurosciences, King's College London, and the Maudsley Hospital, London, UK., Scocco P; SOPROXI Onlus, Padova, Italy., Schulze U; University of Ulm, Department of Child and Adolescent Psychiatry/ Psychotherapy, Ulm, Germany.; Centre for Psychiatry Calw, Clinic for Child and Adolescent Psychiatry and Psychotherapy, Böblingen, Germany., Singh S; Warwick Medical School, University of Warwick, Warwick, United Kingdom. S.P.Singh@warwick.ac.uk., Squarcia A; Child and Adolescent Neuropsychiatry, Department of Mental Health, AUSL di Parma, Parma, Italy., Stagi P; Child and Adolescent Neuropsychiatry, Azienda USL Toscana Centro, Firenze, Italy., Street C; Warwick Medical School, University of Warwick, Warwick, United Kingdom., Toffol E; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Tuomainen H; Warwick Medical School, University of Warwick, Warwick, United Kingdom., van Bodegom LS; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands., Vicari S; Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, Rome, 00165, Italy., de Girolamo G; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Corporate Authors: on behalf the MILESTONE Consortium
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jan; Vol. 31 (1), pp. 94-103. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Magno+M%22">Magno M</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Martella+D%22">Martella D</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Leone+S%22">Leone S</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Allibrio+G%22">Allibrio G</searchLink>; Child and Adolescent Neuropsychiatry, ASST Bergamo Ovest, Treviglio, Italy.<br /><searchLink fieldCode="AU" term="%22Bertani+A%22">Bertani A</searchLink>; Unit of Youth Psychopathology, ASST Santi Paolo e Carlo, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Caselani+E%22">Caselani E</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+P%22">Conti P</searchLink>; Child and Adolescent Neuropsychiatry, ASST Lariana, Como, Italy.<br /><searchLink fieldCode="AU" term="%22Cortese+S%22">Cortese S</searchLink>; Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences [CNS and Psychiatry], Faculty of Medicine, University of Southampton, Southampton, UK.; Solent NHS Trust, Southampton, UK.; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, New York, USA.; DiMePRe-J-Department of Precision and Rigenerative Medicine-Jonic Area, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Dieleman+G%22">Dieleman G</searchLink>; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Franic+T%22">Franic T</searchLink>; University Hospital of Split, Department of Psychiatry, Medical School University of Split, Split, Croatia.<br /><searchLink fieldCode="AU" term="%22Gerritsen+S%22">Gerritsen S</searchLink>; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maffezzoni+D%22">Maffezzoni D</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Margari+F%22">Margari F</searchLink>; Dept of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Martinelli+O%22">Martinelli O</searchLink>; Child and Adolescent Neuropsychiatry, ASST Lecco, Lecco, Italy.<br /><searchLink fieldCode="AU" term="%22McNicholas+F%22">McNicholas F</searchLink>; Lucena Clinic, Child and Adolescent Mental Health Services, Saint John of God, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.; Children's Health Ireland at Crumlin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Micciolo+R%22">Micciolo R</searchLink>; Centre for Medical Sciences, Department of Psychology and Cognitive Sciences, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Nacinovich+R%22">Nacinovich R</searchLink>; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.; Child and Adolescent Neuropsychiatry, IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Purper+Ouakil+D%22">Purper Ouakil D</searchLink>; University Hospital of Montpellier, MPEA1, Montpellier, France.; INSERM U 1018 CESP, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Pastore+A%22">Pastore A</searchLink>; Policlinico Hospital, Unit of Adolescent Psychiatric Emergency, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Rinaldi+F%22">Rinaldi F</searchLink>; Child and Adolescent Neuropsychiatry, ASST Valcamonica, Breno, Italy.<br /><searchLink fieldCode="AU" term="%22Santosh+P%22">Santosh P</searchLink>; Institute of Psychiatry, Psychology and Neurosciences, King's College London, and the Maudsley Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Scocco+P%22">Scocco P</searchLink>; SOPROXI Onlus, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Schulze+U%22">Schulze U</searchLink>; University of Ulm, Department of Child and Adolescent Psychiatry/ Psychotherapy, Ulm, Germany.; Centre for Psychiatry Calw, Clinic for Child and Adolescent Psychiatry and Psychotherapy, Böblingen, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Warwick Medical School, University of Warwick, Warwick, United Kingdom. S.P.Singh@warwick.ac.uk.<br /><searchLink fieldCode="AU" term="%22Squarcia+A%22">Squarcia A</searchLink>; Child and Adolescent Neuropsychiatry, Department of Mental Health, AUSL di Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Stagi+P%22">Stagi P</searchLink>; Child and Adolescent Neuropsychiatry, Azienda USL Toscana Centro, Firenze, Italy.<br /><searchLink fieldCode="AU" term="%22Street+C%22">Street C</searchLink>; Warwick Medical School, University of Warwick, Warwick, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Toffol+E%22">Toffol E</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Tuomainen+H%22">Tuomainen H</searchLink>; Warwick Medical School, University of Warwick, Warwick, United Kingdom.<br /><searchLink fieldCode="AU" term="%22van+Bodegom+LS%22">van Bodegom LS</searchLink>; Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vicari+S%22">Vicari S</searchLink>; Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, Rome, 00165, Italy.<br /><searchLink fieldCode="AU" term="%22de+Girolamo+G%22">de Girolamo G</searchLink>; Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
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  Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Jan; Vol. 31 (1), pp. 94-103. <i>Date of Electronic Publication: </i>2025 Oct 17.
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