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Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.

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Title: Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.
Authors: Tang P; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom., Zickuhr GM; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K., Dickson AL; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K., Harding CJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L69 3BX Liverpool, U.K., Devi S; Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, L69 7ZB Liverpool, U.K., Lebl T; School of Chemistry and Biomedical Sciences Research Complex, University of St Andrews and EaStCHEM, North Haugh, St Andrews, Fife KY16 9ST, United Kingdom., Harrison DJ; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K.; NuCana Plc, Edinburgh, EH12 9DT, United Kingdom., da Silva RG; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom., Czekster CM; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.
Source: ACS chemical biology [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2547-2553. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.
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  Data: <searchLink fieldCode="AU" term="%22Tang+P%22">Tang P</searchLink>; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zickuhr+GM%22">Zickuhr GM</searchLink>; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K.<br /><searchLink fieldCode="AU" term="%22Dickson+AL%22">Dickson AL</searchLink>; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K.<br /><searchLink fieldCode="AU" term="%22Harding+CJ%22">Harding CJ</searchLink>; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L69 3BX Liverpool, U.K.<br /><searchLink fieldCode="AU" term="%22Devi+S%22">Devi S</searchLink>; Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, L69 7ZB Liverpool, U.K.<br /><searchLink fieldCode="AU" term="%22Lebl+T%22">Lebl T</searchLink>; School of Chemistry and Biomedical Sciences Research Complex, University of St Andrews and EaStCHEM, North Haugh, St Andrews, Fife KY16 9ST, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harrison+DJ%22">Harrison DJ</searchLink>; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, U.K.; NuCana Plc, Edinburgh, EH12 9DT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22da+Silva+RG%22">da Silva RG</searchLink>; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Czekster+CM%22">Czekster CM</searchLink>; School of Biology, Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2025 Nov 21; Vol. 20 (11), pp. 2547-2553. <i>Date of Electronic Publication: </i>2025 Oct 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101282906 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1554-8937 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215548929%22">15548929 </searchLink><i>NLM ISO Abbreviation: </i>ACS Chem Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acschembio.5c00120
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              Text: 2025 Nov 21
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