Discovery of a new selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment.
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| Title: | Discovery of a new selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment. |
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| Authors: | Bufalieri F; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Cucinotta A; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Cammarone S; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, 00185 Rome, Italy., Agnoli F; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Basili I; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; Institut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée Ligue Contre le Cancer, Orsay, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée Ligue Contre le Cancer, Orsay, France., Ferri G; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Quaglio D; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, 00185 Rome, Italy., Caimano M; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Capriotti AL; Department of Chemistry, Sapienza University of Rome, 00185 Rome, Italy., Montone CM; Department of Chemistry, Sapienza University of Rome, 00185 Rome, Italy., Lospinoso Severini L; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Tempora P; Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., D'Amico S; Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., Juretich F; Department of Scienze del Farmaco, University of Piemonte Orientale, 28100 Novara, Italy., Semrau MS; Protein Targets for Drug Discovery Lab, Elettra Sincrotrone Trieste S.C.p.A, 34149 Basovizza, Trieste, Italy., Navacci S; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Conenna M; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Bordone R; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Spallotta F; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, 00185 Rome, Italy., Garavaglia S; Department of Scienze del Farmaco, University of Piemonte Orientale, 28100 Novara, Italy., Storici P; Protein Targets for Drug Discovery Lab, Elettra Sincrotrone Trieste S.C.p.A, 34149 Basovizza, Trieste, Italy., Ghirga F; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, 00185 Rome, Italy., Laganà A; Department of Chemistry, Sapienza University of Rome, 00185 Rome, Italy., Locatelli F; Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., Ayrault O; Institut Curie, PSL Research University, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée Ligue Contre le Cancer, Orsay, France; Université Paris-Saclay, INSERM U1330/CNRS EMR 8001, Children's Oncology Research Unit (CONCERT), Equipe Labellisée Ligue Contre le Cancer, Orsay, France., Infante P; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Botta B; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, 00185 Rome, Italy., Mori M; Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100 Siena, Italy. Electronic address: mattia.mori@unisi.it., Fruci D; Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy. Electronic address: doriana.fruci@opbg.net., Di Marcotullio L; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy. Electronic address: lucia.dimarcotullio@uniroma1.it. |
| Source: | Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jan 07; Vol. 34 (1), pp. 582-605. Date of Electronic Publication: 2025 Oct 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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