CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success.

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Title: CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success.
Authors: Ludin A; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Stirtz GL; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Tal A; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Nirmal AJ; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Manos M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Besson N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Eskndir N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Porter B; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Jones SM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Faulkner HM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Gong Q; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Liu S; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Barrera I; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Wu L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Pessoa Rodrigues C; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Sahu A; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Jerison E; Department of Physics, University of Chicago, Chicago, IL 60637, USA., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Richardson DS; Harvard Center for Biological Imaging, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Weiss JD; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Moreau HM; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Stanhope ME; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Afeyan AB; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Sefton J; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., McCall WD; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Formato E; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Yang S; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Zhou Y; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Hoytema van Konijnenburg DP; Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Cole HL; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Cordova M; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Deng L; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Rajadhyaksha M; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Quake SR; Department of Bioengineering and Applied Sciences, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Chen F; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Sorger PK; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Hodi FS; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy, Boston, MA, USA., Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Murphy GF; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zon LI; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: leonard.zon@enders.tch.harvard.edu.
Source: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6720-6736.e26. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2025.09.021