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CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success.

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Title: CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success.
Authors: Ludin A; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Stirtz GL; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Tal A; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Nirmal AJ; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Manos M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Besson N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Eskndir N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Porter B; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Jones SM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Faulkner HM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Gong Q; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Liu S; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Barrera I; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Wu L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Pessoa Rodrigues C; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Sahu A; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Jerison E; Department of Physics, University of Chicago, Chicago, IL 60637, USA., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Richardson DS; Harvard Center for Biological Imaging, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Weiss JD; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Moreau HM; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Stanhope ME; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Afeyan AB; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Sefton J; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., McCall WD; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Formato E; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Yang S; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Zhou Y; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA., Hoytema van Konijnenburg DP; Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Cole HL; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA., Cordova M; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Deng L; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Rajadhyaksha M; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Quake SR; Department of Bioengineering and Applied Sciences, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Chen F; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Sorger PK; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Hodi FS; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy, Boston, MA, USA., Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Murphy GF; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zon LI; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: leonard.zon@enders.tch.harvard.edu.
Source: Cell [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6720-6736.e26. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: CRATER tumor niches facilitate CD8<superscript>+</superscript> T cell engagement and correspond with immunotherapy success.
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  Data: <searchLink fieldCode="AU" term="%22Ludin+A%22">Ludin A</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Stirtz+GL%22">Stirtz GL</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Tal+A%22">Tal A</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Nirmal+AJ%22">Nirmal AJ</searchLink>; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Pfaff+KL%22">Pfaff KL</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Manos+M%22">Manos M</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Besson+N%22">Besson N</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Eskndir+N%22">Eskndir N</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Porter+B%22">Porter B</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Jones+SM%22">Jones SM</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Faulkner+HM%22">Faulkner HM</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Gong+Q%22">Gong Q</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Barrera+I%22">Barrera I</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Pessoa+Rodrigues+C%22">Pessoa Rodrigues C</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Sahu+A%22">Sahu A</searchLink>; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Jerison+E%22">Jerison E</searchLink>; Department of Physics, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Alessi+JV%22">Alessi JV</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ricciuti+B%22">Ricciuti B</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+DS%22">Richardson DS</searchLink>; Harvard Center for Biological Imaging, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+JD%22">Weiss JD</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Moreau+HM%22">Moreau HM</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Stanhope+ME%22">Stanhope ME</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Afeyan+AB%22">Afeyan AB</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Sefton+J%22">Sefton J</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22McCall+WD%22">McCall WD</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Formato+E%22">Formato E</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hoytema+van+Konijnenburg+DP%22">Hoytema van Konijnenburg DP</searchLink>; Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Cole+HL%22">Cole HL</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Cordova+M%22">Cordova M</searchLink>; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Deng+L%22">Deng L</searchLink>; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Rajadhyaksha+M%22">Rajadhyaksha M</searchLink>; Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Quake+SR%22">Quake SR</searchLink>; Department of Bioengineering and Applied Sciences, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Awad+MM%22">Awad MM</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wucherpfennig+KW%22">Wucherpfennig KW</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Sorger+PK%22">Sorger PK</searchLink>; Ludwig Center at Harvard, Boston, MA 02115, USA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hodi+FS%22">Hodi FS</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Parker Institute for Cancer Immunotherapy, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rodig+SJ%22">Rodig SJ</searchLink>; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+GF%22">Murphy GF</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zon+LI%22">Zon LI</searchLink>; Harvard Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA 02138, USA; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: leonard.zon@enders.tch.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2025 Nov 26; Vol. 188 (24), pp. 6720-6736.e26. <i>Date of Electronic Publication: </i>2025 Oct 17.
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